|
|
|
| Significance of detection of cervical epithelial cell stability free ferrous protoporphyrin in the diagnosis of cervical cancer in different ages |
| ZHAO Ying ZHOU Xunhua CHEN Yanhui |
| Department of Gynecology and Obstetrics, Hu'nan Brain Hospital, Hu'nan Province, Changsha 410007, China |
|
|
|
Abstract Objective To investigate the significance of detection of cervical epithelial cell stability free ferrous protoporphyrin (FH) in the diagnosis of cervical cancer in different ages. Methods The clinical data of 213 cases of patients with cervical tumor admitted to Hu'nan Brain Hospital from October 2014 to October 2017 was retrospectively analyzed. They were divided into 6 age groups of ≤30 years old, >30-40 years old, ＞40-50 years old, ＞50-60 years old, ＞60-70 years old, and ＞70 years old by age, and all the patients were treated with surgical treatment and diagnosed by pathological examination, also they were detected by cervical epithelial cells stability FH. The results of FH detection at different ages were compared, and the sensitivity, specificity and accuracy of FH test in different age groups were analyzed, then the receiver operating curves (ROC) of patients with high-risk cervical cancer in different age groups based on uterine epithelial cells stability FH were made, and the area under curves (AUC) were obtained. Results The total positive rates of people at age of ＞40-50 years old and ＞60-70 years old were significantly higher than those of ≤30 years old, ＞30-40 years old, ＞50-60 years old and ＞70 years old (P ＜ 0.05), but there were no significant differences between the other age groups (P ＞ 0.05). There were respectively 10, 25, 56, 9, 50 cases and 11 cases of ≤30 years old, ＞30-40 years old, ＞40-50 years old, ＞50-60 years old, ＞60-70 years old and ＞70 years old by cervical epithelial cells stability FH, while there were respectively 7, 21, 55, 7, 49 cases and 8 cases of ≤30 years old, ＞30-40 years old, ＞40-50 years old, ＞50-60 years old, ＞60-70 years old and ＞70 years old by immunocytochemistry examination. Epithelial cells stability FH detection had higher sensitivity, specificity and accuracy in different age groups, which of ＞40-50 years old and ＞60-70 years old were higher than other age groups. The AUC of the uterine epithelial cells stability FH for the detection of people at age of ＞40-50 years old, ＞60-70 years old, ＞30-40 years old, ＞70 years old, ＞50-60 years old, and ≤30 years old were 0.956, 0.949, 0.819, 0.763, 0.727 and 0.727 respectively. Conclusion Cervical epithelial cells stability FH staining are reliable in the diagnosis of cervical cancer at different ages, but the sensitivity, specificity and accuracy of ＞40-50 years old and ＞60-70 years old are relatively higher other ages, which can be used to guide clinical screening and diagnosis of cervical cancer.
|
|
|
|
|
|
[1] 周晖，林仲秋.美国国立综合癌症网络“2016宫颈癌临床实践指南”解读[J].中国实用妇科与产科杂志，2016， 32（3）：223-230.
[2] 刘慧强.我国宫颈癌流行病学特征和高危因素分析[J].中国妇幼保健，2016，31（6）：1258-1260.
[3] 何晓明，尤志学.2013年WHO宫颈癌筛查及处理方案指南的解读[J].现代妇产科进展，2015，24（3）：220-223.
[4] 孙妙红，何玉立.HPV检测在早期宫颈癌筛查中的临床意义[J].中国妇幼保健，2015，30（17）：2730-2731.
[5] 胡玉芹，刘付强，刘岩丽，等.宫颈上皮细胞稳定性FH检测与TCT技术在宫颈病变筛查中的应用价值[J].河北医科大学学报，2016，37（1）：35-39.
[6] 吴翠霞，张艳红，葛小花，等.高危型HPV感染与宫颈癌前病变与宫颈癌的相关性研究[J].中华医院感染学杂志，2016，26（11）：2568-2570.
[7] Srivastava S，Singh S，Fatima N，et al. Pre-microRNA Gene Polymorphisms and Risk of Cervical Squamous Cell Carcinoma [J]. J Clin Diagn Res，2017，11（9）：31-34.
[8] 王少云，谢东.宫颈液基薄层细胞学检测联合阴道镜在筛查宫颈癌前病变中的价值[J].中国性科学，2015，24（11）：36-39.
[9] Kishore V，Patil AG. Expression of p16INK4A Protein in Cervical Intraepithelial Neoplasia and Invasive Carcinoma of Uterine Cervix [J]. J Clin Diagn Res，2017，11（9）：17-20.
[10] 李姗，宗丽菊，孟丽华，等.子宫上皮细胞稳定性FH检测在诊断宫颈癌及癌前病变中的临床意义[J].中国肿瘤，2015，24（10）：881-883.
[11] Yoshimoto M，Tokuda A，Nishiwaki K，et al. The protein interacting with carboxyl terminus-1 codon 389 polymorphism impairs protein interacting with carboxyl terminus-1 function and is a risk factor for uterine cervical cancer [J]. Mol Carcinog，2017，56（5）：1484-1492.
[12] Stiasny A，Freier CP，Kuhn C，et al. The involvement of E6，p53，p16，MDM2 and Gal-3 in the clinical outcome of patients with cervical cancer [J]. Oncol Lett，2017，14（4）：4467-4476.
[13] 王井，汪洪涛，马华，等.NOX通路在氧化应激诱导的宫颈癌细胞凋亡中的作用[J].山东医药，2017，57（20）：13-16.
[14] Roik EE，Nieboer E，Kharkova OA，et al. Do Cervical Cancer Patients Diagnosed with Opportunistic Screening Live Longer? An Arkhangelsk Cancer Registry Study [J]. Int J Environ Res Public Health，2017，14（12）：1021-1028.
[15] 员周慧，余晓，徐舜，等.子宫上皮细胞稳定性FH检测在宫颈癌前病变中的临床诊断意义分析[J].中国性科学，2016，25（11）：39-41.
[16] Pedersen K，Burger EA，Campbell S，et al. Advancing the evaluation of cervical cancer screening：development and application of a longitudinal adherence metric [J]. Eur J Public Health，2017，27（6）：1089-1094.
[17] 周琦，龙玲，曾莉.宫颈癌患者HPV感染情况分析及其宫颈组织CD4+、CD8+的表达研究[J].中国病原生物学杂志，2016，12（9）：851-854.
[18] 李玉霞，宋晓婕，陈莉，等.宫颈癌筛查中高危型HPV及液基细胞学联合应用的临床价值[J].中国妇幼保健，2015，30（3）：479-481.
[19] 李建红，王培兰，肖鹏，等.老年宫颈癌的临床病理特征分析及预后影响因素探讨[J].基因组学与应用生物学，2017，36（7）：2775-2780.
[20] 覃小敏，李琳，黄艳丽，等.中老年宫颈癌患者预后相关影响因素的分析[J].癌症进展，2015，13（3）：346-349. |
|
|
|
