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| Clinical significance of serum autoantibodies detection in patients with hepatitis B cirrhosis |
| YAN Xiuping HOU Qingshun WANG Hui GUO Lu |
| Liver Disease Ten Area, the Sixth People′s Hospital of Qingdao City, Shandong Province, Qingdao 266033, China |
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Abstract Objective To explore the presence of serum autoantibodies in patients with hepatitis B cirrhosis and its clinical significance. Methods 60 patients with hepatitis B cirrhosis in the Sixth People′s Hospital of Qingdao City from March 2016 to June 2017 were selected and divided into autoantibodies positive group (n=13) and autoantibodies negative group (n=47) according to the test results of serum autoantibodies which were detected with immunoblot. The liver function indexes of ALT, AST, TBil, AKP, GGT and immunoglobulin between two groups were detected by using full automatic biochemical analyzer. Liver instantaneous elastic hardness (Fibroscan) was tested. Results Total positive rate of autoantibodies in patients with hepatitis B cirrhosis was 21.7%. Compared with autoantibody negative group, the age of autoantibody positive group was increased (P < 0.05), the levels of GLB, IgG and Fibroscan were significantly increased in autoantibody positive group (P < 0.05), ALB of autoantibody positive group was decreased (P < 0.05). Conclusion Autoimmune reactions exist in patients with hepatitis B cirrhosis, and cause production of autoantibodies, which are related to the age, the degree of liver damage and liver fibrosis of paients.
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