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| Difference on the levels of Nesfatin-1, C-reactive protein and serum ferritin in different gestational periods in patiens with gestational diabetes mellitus and their relationship |
| JIANG Haiying ZUO Jinling SANG Xuemei WANG Qian ZHAO Jing |
| Department of Gynaceology and Obstetrics, Maternal and Child Health Hospital of Tangshan, Heibei Province, TangShan 063000, China |
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Abstract Objective To investigate the levels of Nesfatin-1, C-reactive protein (CRP) and serum ferritin (SF) of different gestational periods in patients with gestational diabetes mellitus (GDM) and their relationship. Methods From June 2015 to January 2017, 103 patients in early pregnancy built profile and examined in Maternal and Child Health Hospital of Tangshan were selected as research objects and divided into the test group (47 cases) and the control group (56 cases) by the oral glucose tolerance test. The general conditions (includes age, gestational weeks, BMI, fasting blood glucose and fasting insulin) in middle pregnancy between the two groups were compared and the levels of Nesfatin-1, CRP and SF in the early and middle pregnancy between the two groups were compared. The logistic regression analysis was used to analyze the related factors of GDM. Results There were no statistically significant differences in the age, gestational weeks and BMI between the two groups in the middle pregnancy (P ＞ 0.05). The fasting blood glucose and fasting insulin in the test group were higher than those of control group, with statistically significant differences(P ＜ 0.05). In the early and middle pregnancy, the levels of Nesfatin-1, CRP and SF in the test group were higher than those of control group, with statistically significant differences (P ＜ 0.05). In the test group, the indicators above in the middle pregnany were higher than those of early pregnany, with statistically significant differences (P ＜ 0.05); in the control group, there were no statistically significant differences in the above indicators between the early and middle pregnany (P ＜ 0.05). The Logistic regressive analysis showed that the fasting blood glucose, fasting insulin, Nesfatin-1,CRP and SF were the risk factors of GDM (P ＜ 0.05). Conclusion Serum Nesfatin-1, CRP and SF are the risk factors of GDM. In early pregnancy of GDM patients, Nesfatin-1, CRP and SF are higher than those in normal pregnant women and it is helpful for early detection of GDM, so as to control the patients′ blood glucose effectively, which is of great significance to improve the pregnancy outcome.
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