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| Effect of growth hormone in the treatment of patients with severe intrauterine adhesions and its effect on the outcome of pregnancy and the level of inflammatory cytokines |
| YANG Li WU Huizhen GAN Haisi |
| Department of Obstetrics and Gynecology, Affiliated Hospital of Youjiang Medical University for Nationalities, Guangxi Zhuang Autonomous Region, Baise 533000,China |
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Abstract Objective To investigate the effect of growth hormone on the treatment of patients with severe intrauterine adhesions and its effect on the outcome of pregnancy and the level of inflammatory cytokines. Methods Sixty-six patients with severe intrauterine adhesions treated in Obstetrics and Gynecology of Affiliated Hospital of Youjiang Medical University for Nationalities from June 2014 to March 2017 were selected as study subjects, and all patients were divided into control group (intrauterine adhesions separation surgery + estrogen therapy) + observation group (intrauterine adhesions separation + estrogen + growth hormone intervention) according to whether usedgrowth hormone, each group had 33 cases. The clinical treatment effect and pregnancy outcomes were compared between two groups, the levels of inflammatory cytokines interleukin-6 (IL-6), interleukin-8 (IL-8) and tumor necrosis factor-α (TNF-α) were measured by enzyme linked immunosorbent assay. Results The improvement rate of menstruation in the observation group was significantly higher than that in the control group (χ2=4.232, P=0.039), and the intrauterine readhesion rate was also significantly lower than that in the control group (χ2=3.995, P=0.046). The pregnancy success rate was significantly higher than that of the control group (χ2=3.986, P=0.046), but there was no significant difference in the incidence of adverse reactions between the two groups (χ2=0.733, P=0.392). The endometrial thickness of the observation group was significantly higher than that of the control group (P < 0.05). However, there was no significant difference in endometrial volume, resistance index and pulsatility index between the two groups (P > 0.05). In addition, the levels of IL-6, IL-8 and TNF-α in the observation group were significantly lower than those in the control group after the treatment (P < 0.05). Conclusion Growth hormone can significantly improve the treatment of patients with intrauterine adhesions, improve pregnancy outcomes, reduce the level of inflammatory cytokines.
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