肠促胰素类药物治疗非酒精性脂肪性肝病研究进展

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Abstract Type 2 diabetes mellitus is closely associated with non-alcoholic fatty liver disease (NAFLD), which is the most prevalent chronic liver disease worldwide. Currently, the only validated treatment for NAFLD is lifestyle intervention. Glucagon like peptide-1 receptor agonists and dipeptidyl peptidase-4 inhibitors, collectively termed incretin-based therapies, represent two of the most widely used classes of novel antidiabetic drugs. A number of studies of human trials have evaluated the effects of incretins on liver fat content and suggest that the treatment could represent a new alternative for NAFLD management. In this paper, the main clinical studies regarding the effects of incretins on NAFLD are reviewed.

Key words： Nonalcoholic fatty liver disease Incretins Glucagon-like peptide-1 Dipeptidy peptidase-4 Liver fat content

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	PANG Baoying KUANG Hongyu▲

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PANG Baoying KUANG Hongyu▲. Research progress of incretin-based therapies on nonalcoholic fatty liver disease[J]. 中国医药导报, 2018, 15(6): 28-30,34.

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http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2018/V15/I6/28

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