针灸联合活血通络汤治疗脑卒中后认知功能障碍的临床研究

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Abstract Objective To investigate the effects of acupuncture combined with Huoxue Tongluo Decoction in the treatment of post-stroke cognitive impairment. Methods A total of 79 patients with post-stroke cognitive impairment in Wuhan Eleventh Hospital from January 2015 to December 2016 were enrolled in this study. The subjects were randomly divided into the control group (39 cases) and the treatment group (40 cases). The control group was treated with Huoxue Tongluo Decoction, the treatment group was treated with acupuncture combined with Huoxue Tongluo Decoction. The two groups were treated for 30 days. The clinical effects of the two groups after treatment were compared. The cognitive function by mini-mental state examination (MMSE) was evaluated, the levels of serum cortisol (Cor) and heat shock protein 70 (heat shock protein 70, HSP70) were detected before and after treatment, the adverse reactions of the two groups during treatment were observed. Results The total effective rate of the treatment group was significantly higher than that of control group (P ＜ 0.05). After treatment, the MMSE score of the two groups was significantly higher than that before treatment, the MMSE score of the treatment group was significantly higher than that of control group (P ＜ 0.05). After treatment, the levels of serum Cor in the two groups were significantly lower than those before treatment, the levels of serum HSP70 in the two groups were significantly higher than those before treatment, and the changes of serum Cor and HSP70 levels after treatment in the treatment group were significantly better than those in the control group, the differences were statistically significant (P ＜ 0.05). There were no significant adverse reactions in the two groups during the treatment. Conclusion Acupuncture combined with Huoxue Tongluo Decoction for patients with post-stroke cognitive impairment has a good efficacy, which can improve the cognitive function and neurologic prognosis, with good safety, and it is worthy of clinical promotion and application.

Key words： Acupuncture Huoxue Tongluo Decoction Post-stroke cognitive impairment Efficacy

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	JIA Yunzhe1 LYU Xiaoyu2

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JIA Yunzhe1 LYU Xiaoyu2. Clinical study of acupuncture combined with Huoxue Tongluo Decoction in the treatment of post-stroke cognitive impairment[J]. 中国医药导报, 2018, 15(4): 113-116.

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http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2018/V15/I4/113

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