丙泊酚与七氟烷全麻对梗阻性黄疸患者影响的比较

Abstract
Figure/Table
References (22)
Related Citation (2)

Download: PDF (444 KB) HTML (1 KB)
Export: BibTeX | EndNote (RIS)

Abstract Objective To compare the anesthesia of Propofol target controlled infusion and Sevoflurane inhalation anesthesia recovery time and recovery of patients with obstructive jaundice of the bispectral index （BIS）, the influence of adverse reactions and postoperative extubation time. Methods From January 2016 to May 2017, 72 patients of general anesthesia on downward abdominal surgery in Maoming Hospital of Chinese Medicine Affiliated to Guangzhou University of Chinese Medicine, all were ASA I or Ⅱ, according to the serum level of total bilirubin they were divided into jaundice group and non jaundice group, with 36 cases in each group, then the jaundice group and non jaundice group were randomly divided into Propofol group A, B and Sevoflurane group A, B, with 18 cases in each group. The awakening time, BIS, extubation time and postoperative adverse reaction of each groups were recorded. Results The recovery time, BIS, and extubation time of patients in the Sevoflurane group A were the longest, the recovery time, BIS at recovery time and extubation time of patients in the Propofol group A were significantly shorter than those in Sevoflurane group A, the differences were statistically significant （P < 0.05）. BIS, recovery time and extubation time of patients in the Propofol group B were longer than those of the Sevoflurane group B, the differences were statistically significant （P < 0.05）. The incidence of PONV, dizziness and drowsiness 24 h after surgery of patients in the Propofol group B was significantly lower than that in the Sevoflurane group B, and the incidence of PONV, dizziness and drowsiness 24 h after surgery in the Propofol group A was lower than that in the Sevoflurane group A, the differences were statistically significant （P < 0.05）. Conclusion Propofol target controlled infusion anesthesia has a lower rate of PONV and more rapid recovery compared with Sevoflurane patients with obstructive jaundice, and the anesthetic effect of Propofol is better than that of Sevoflurane.

Key words： Obstructive jaundice Propofol Recovery time Postoperative adverse reaction

	Service

	E-mail this article
	Add to my bookshelf
	Add to citation manager
	E-mail Alert
	RSS
	Articles by authors
	ZHANG Xiaohua1 LI Xirong2 LI Yuchan1 ZHANG Jinxiong1 XIONG Xiang3

Cite this article:

ZHANG Xiaohua1 LI Xirong2 LI Yuchan1 ZHANG Jinxiong1 XIONG Xiang3. Comparison on the effects of Propofol and Sevoflurane on patients with obstructive jaundice during general anesthesia[J]. 中国医药导报, 2018, 15(4): 86-89.

URL:

http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2018/V15/I4/86

[1] 陈英强.健忘镇痛慢诱导气管插管对梗阻性黄疸患者麻醉诱导期血流动力学的影响[J].中国现代医生，2015，53（26）：169-170.
[2] 徐刚.恶性梗阻性黄疸研究现状及进展[J].中国医药科学，2012，2（24）：29-30.
[3] 陈英强.健忘镇痛慢诱导气管插管对梗阻性黄疸患者麻醉诱导期血流动力学的影响[J].中国现代医生，2015，53（26）：103-105.
[4] 汝建芬.右美托咪定对小儿七氟醚麻醉苏醒期躁动的预防价值探讨[J].医学理论与实践，2015，28（24）：3377-3378.
[5] 张燕，詹琼慧，陈珏.七氟醚预处理对肾缺血再灌注损伤中HIF-2a表达的影响[J].上海交通大学学报：医学版，2015，35（12）：1800-1803.
[6] 沈洪，苏子敏，仓静，等.七氟醚、异氟醚或丙泊酚全身麻醉复合硬膜外阻滞对肝脏切除术后肝肾功能的影响[J].临床麻醉学杂志，2007，23（8）：624-626.
[7] 罗艳，姚尚龙，杨拔贤，等.中国麻醉医师在全身麻醉中七氟醚使用习惯的多中心研究[J].临床麻醉学杂志，2016， 32（1）：6-9.
[8] 郝倩，周莉，刘保江等脑电双频谱指数和Narcotrend监测临床应用新进展[J].中华临床医师杂志：电子版，2016， 10（4）：588-592
[9] 黄达，王东信.脑电双频指数监测临床应用的新进展[J].国际麻醉学与复苏杂志，2014，35（9）：825-829
[10] 梁超，丁明，杜芳，等.七氟醚联合丙泊酚麻醉维持在全麻复合硬膜外麻醉中的临床应用[J].中国临床医学，2016， 23（3）：324-326.
[11] 万静洁，李真，金宁，等.小剂量七氟醚或笑气复合丙泊酚对宫腔镜术后恶心呕吐的影响[J].中国医科大学学，2016，45（1）：77-82.
[12] 夏明，谢军明，刘杨，等.亚麻醉剂量丙泊酚对术后恶心呕吐的作用研究[J].现代生物医学进展，2010，19（10）：3682-3684.
[13] Criswell HE，Ming Z，Pleasant N，et al. Macrokinetie analysis of blockade of NMDA-gated currents by substituted alcohols，alkanes andethers I [J]. Brain Res，2004，1015（1-2）：107-113.
[14] 宋金超，俞卫锋，张马忠，等.梗阻性黄疸患者靶控输注异丙酚的药代动力学[J].中华麻醉学杂志，2006，26（10）：869-872.
[15] Okano N，Fujita N，Kadoi Y，el al. Disturbances in hepatoceUular function during cardiopulmonary bypass using propofol anaesthesia [J]. Eur J Anaesth，2001，18（12）：798-804
[16] Le Guellec C，Laearelle B，Viuard PH，et al. Glucurenidation of propofol in micmsomal fractions from various tissues and species including human：effect of different drugs [J]. Anesth Analg，1995，81（4）：855-861.
[17] Shi HB，Kakazu Y，Shibata S，et al. Bilirubin potentiates inhibitory synaptic transmission in lateral superior oliveneurons of the rat [J]. Neurosci Res，2006，55（2）：161-170.
[18] 于洋.丙泊酚与七氟醚复合麻醉对肝炎肝硬化患者肝肾功能的影响[J].中国实用医药，2017，12（3）： 123-124.
[19] Sohwieler L，Delbro DS，Engberg G，et al. The anaesthetic agent propofol interacts with GABA ncceptors：an eleetrophysiologieal study in rat [J]. Life Sci，2003，72（24）：2793-2801.
[20] 高浩，宋金超，张马忠，等.梗阻性黄疸对全麻术中丙泊酚用量的影响[J].临床麻醉学杂志，2016，32（11）：1062-1063.
[21] Daood MJ，McDonagh AF，Watchko JF. Calculated free bilirubin levels and neurotoxicity [J]. J Perinatol，2009， 29 Suppl 1（Suppl 1）：S14-S19.
[22] Song JG，Cao YF，Yang LQ，et al. Awakening concentration of desflurane is decreased in patients with obstructive jaundice [J]. Anesthesiology，2005，102（3）：562-565.