阻塞性睡眠呼吸暂停综合征患者血清同型半胱氨酸、胱抑素C表达水平及临床价值

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Abstract Objective To explore the expression level of homocysteine and cystatin C in patients with obstructive sleep apnea syndrome and its clinical value. Methods From January 2015 to July 2017, 174 patients with OSAHS in People′s Hospital of Linqu County were selected as the OSAHS group. At the same time, 90 healthy people in the same hospital were selected as the control group. The levels of serum homocysteine and cystatin C in the two groups were compared. Pearson correlation analysis was used to analyze the correlation of homocysteine, cystatin C and apnea hypopnea index (AHI). Patients in OSAHS group were divided into mild, moderate and severe OSAHS group according to the severity of the disease and the homocysteine, Cystatin C in the three groups were compared. Results The homocysteine and cystatin C in the OSAHS group were higher than those of control group, with highly statistically significant differences (P ＜ 0.01). Pearson correlation analysis showed that serum homocysteine and cystatin C were positively correlated with AHI, with highly statistically significant differences (r = 0.79,0.74,P ＜ 0.01). There were statistically significant differences in homocysteine and cystatin C among the three OSAHS groups (P ＜ 0.05), the above indicators in moderate and severe OSAHS group were higher than those of mild OSAHS group and those in the severe OSAHS group were higher than those of moderate OSAHS group, with statistically significant differences (P ＜ 0.05). Conclusions The level of serum homocysteine and cystatin C in patients with OSAHS were significantly higher than those of normal population and are positively correlated with AHI, which can be used as a sensitive indicator for the diagnosis and evaluation of OSAHS.

Key words： Obstructive sleep apnea syndrome Homocysteine cystatin C Correlation analysis

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	WANG Shanquan1 LIU Chengzhou1 LIU Tongxiang2

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WANG Shanquan1 LIU Chengzhou1 LIU Tongxiang2. Levels and clinical value of serum homocysteine and cystatin C in patients with obstructive sleep apnea syndrome[J]. 中国医药导报, 2018, 15(4): 73-76.

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http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2018/V15/I4/73

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