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Discussion on the treatment of primary liver cancer based on the theory of deficiency, toxin and stasis |
DANG Zhibo1,2 YAN Jun3 LI Lingru4 LI Ling1,2 ZHOU Yichi1,2 HU Shiping2 |
1.Department of Gastroenterology, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing 100700, China;
2.Department of Hepatology, Shenzhen Hospital, Beijing University of Chinese Medicine, Guangdong Province, Shenzhen 518100, China;
3.Department of Pulmonary Disease, Zaozhuang Hospital, Beijing University of Chinese Medicine, Shandong Province, Zaozhuang 277000, China;
4.Center for Physical and Reproductive Medicine, Beijing University of Chinese Medicine, Beijing 100029, China |
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Abstract Primary liver cancer is a common malignant tumor in clinical practice. Its incidence rate and mortality rate are all high. Traditional Chinese medicine for liver function Child-Pugh B and C grade patients with related treatment indications can take the treatment of syndrome differentiation, improve the quality of life of patients, prolong the survival period, whitch belongs to the first-line treatment strategy. From the perspective of traditional Chinese medicine, the pathogenesis of primary liver cancer is deficiency of vital energy and internal invasion of external evils, resulting in dysfunction of viscera function, abnormal metabolism of qi, blood and body fluid, deficiency of vital energy for a long time, phlegm turbidity, blood stasis, cancer toxin endogenous and stagnation in the liver, resulting in tangible masses. The treatment should be based on the treatment of liver and spleen, pay attention to qi and blood stasis, and at the same time, do not forget to detoxify.
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[1] Bray F,Ferlay J,Soerjomataram I,et al. Global cancer statistics 2018:GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries [J]. CA Cancer J Clin,2018,68(6):394-424.
[2] 郑荣寿,孙可欣,张思维,等.2015年中国恶性肿瘤流行情况分析[J].中华肿瘤杂志,2019,41(1):19-28.
[3] 中华人民共和国卫生和计划生育委员会医政医管局.原发性肝癌诊疗规范(2017年版)[J].中华肝脏病杂志,2017,25(12):886-895.
[4] 赵文霞.原发性肝癌中西医结合治疗进展与思考[J].中西医结合肝病杂志,2019,29(2):114-117.
[5] 汪娟.黄芪的药理作用研究进展[J].医疗装备,2018,31(14):202-203.
[6] 朱天友.中药黄芪的现代临床应用及研究现状[J].中国医药指南,2018,16(15):42-43.
[7] 安小翠,朱瑞雪,蔺淑梅,等.黄芪甲苷抑制ROS NF-κB信号通路促进肝癌细胞增殖、凋亡的作用机制[J].现代消化及介入诊疗,2019,24(12):1399-1403.
[8] 王雪林,李杨,刘丹,等.黄芪多糖对黄嘌呤氧化酶诱导的肺癌A549细胞自噬及PI3K/AKT信号通路的影响[J].中国药理学通报,2019,35(12):1676-1680.
[9] 胡光星,张焕峰.中药黄芪的药理及临床应用价值分析[J].临床医药文献电子杂志,2019,6(93):166,169.
[10] 孙晓卉,张量.柴胡药理作用的研究进展[J].中国医药导报,2017,14(10):52-55.
[11] 吴勤祥,李好朝,乔泽强,等.柴胡皂苷D对人肝癌HepG2细胞系增殖和裸鼠肝癌形成的抑制作用[J].中国免疫学杂志,2018,34(11):1664-1668.
[12] 王宗明,王敏,肖欢智.柴胡皂苷D通过调控mTORC信号通路诱发肝癌细胞自噬的作用研究[J].中国药学杂志,2018,53(19):1652-1657.
[13] 曹秋梅,许周洁,聂源,等.浅析小柴胡汤近十年药理研究与临床应用[J].亚太传统医药,2017,13(2):76-77.
[14] 李乃谦.探讨白芍的药理作用及现代研究进展[J].中医临床研究,2017,9(20):137-138.
[15] 张弛,杨良俊,李菁,等.基于网络药理学的白芍-柴胡药对治疗肝细胞癌的作用机制探析[J/OL].中华中医药学刊.[2020-02-17]. http://kns.cnki.net/kcms/detail/21. 1546.R.20190912.1400.012.html.
[16] 邸莎,赵林华,杨映映,等.白芍的临床应用及其用量探究[J].环球中医药,2019,12(2):266-269.
[17] 马莹慧,王艺璇,刘雪,等.丹参药理活性研究进展[J].吉林医药学院学报,2019,40(6):440-442.
[18] 陈曦,柏林,王映映,等.丹参酮ⅡA对人肝癌HepG2细胞增殖和迁移的抑制作用及促凋亡作用[J].吉林大学学报:医学版,2019,45(3):531-538.
[19] 成薇婷,许凯.丹参酮ⅡA通过调控自噬抑制乏氧诱导的肝内胆管细胞癌侵袭能力的研究[J].内科急危重症杂志,2016,22(5):373-376.
[20] 唐尹萍,刘焱文.鳖甲研究概况[J].中国药师,2010,13(3):423-425.
[21] 刘思鸿,李莎莎,侯酉娟,等.《金匮要略》鳖甲煎丸临床应用的古今文献研究[J].中国实验方剂学杂志,2020, 26(6):12-17.
[22] 郭晓华,王仕宝.中药材重楼研究进展[J].陕西农业科学,2019,65(5):94-98.
[23] 孟巍,杜娟,陈涛.重楼的化学成分及其抗肿瘤机制[J/OL]. 生命的化学,2020. [2020-02-17]. https://doi.org/10.13488/j.smhx.20190114.
[24] 张振,郜文辉,田雪飞,等.基于PI3K/mTOR通路益气化瘀解毒方对人肝癌细胞SMCC-7721自噬流的影响[J].中国中医药信息杂志,2019,26(10):45-49.
[25] Man S,Chai H,Cui J,et al. Antitumor and anti-metastatic mechanisms of Rhizoma paridis saponins in Lewis mice [J]. Environ Toxicol,2018,33(2):149-155.
[26] 洪燕,韩燕全,桂洁,等.重楼醇提物对小鼠免疫性肝损伤保护作用[J].辽宁中医药大学学报,2013,15(5):31-33. |
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