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| Effect of benefiting qi for activating blood circulation method on diastolic heart failure patients with syndrome of qi deficiency and blood stasis |
| LIU Xiaoxia1 WANG Jun1 SHEN Xiaoxu2 |
1.Department of Cardiology, Langfang Hospital of Traditional Chinese Medicine, Hebei Province, Langfang 065000, China;
2.Department of Cardiology, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing 100700, China |
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Abstract Objective To observe the effect of benefiting qi for activating blood circulation method on diastolic heart failure (DHF) patients with syndrome of qi deficiency and blood stasis. Methods Eighty-nine DHF patients with syndrome of qi deficiency and blood stasis in Department of Cardiology of Langfang Hospital of Traditional Chinese Medicine from January 2017 to November 2019 were selected and divided into control group (44 cases) and observation group (45 cases) according to odd and even number. Control group was given basic symptomatic treatment of Western medicine, and observation group was additionally treated with Yishen Qiangxin Decoction for eight weeks. Traditional Chinese medicine syndrome score, curative effect, cardiac function index, ventricular remodeling index and cytokine levels before and after treatment were compared between two groups. Results After eight weeks of treatment, the scores of palpitation and shortness of breath, asthma, chest tightness and dull pain, mental fatigue and chest pain in two groups were lower than those before treatment, and observation group was lower than that of control group, the differences were statistically significant (P < 0.05). The curative effect of observation group was better than that of control group, and the difference was statistically significant (P < 0.05). After eight weeks of treatment, cardiac function grade, peak velocity of early diastolic mitral flow (E)/peak velocity of mid late diastolic blood flow (A) of two groups were higher than those before treatment, E of two groups was faster than that before treatment, six-minute walk test (6MWT) of two groups was longer than that before treatment, and cardiac function grade, E/A of observation group were higher than those of control group, E of observation group was faster than that of control group, 6MWT of observation group was longer than that of control group, the differences were statistically significant (P < 0.05). After eight weeks of treatment, the left ventricular end diastolic diameter (LVEDD), end diastolic ventricular septal thickness (IVST) of two groups were shorter than those before treatment, left ventricular end diastolic volume (LVEDV) of two groups was less than that before treatment, left ventricular mass index (LVMI) of two groups was lower than that before treatment, and LVEDD and IVST of observation group were shorter than those of control group, LVEDV of observation group was less than that of control group, LVMI of observation group was lower than that of control group, the differences were statistically significant (P < 0.05). After eight weeks of treatment, the levels of cardiac troponin I (cTnI), high sensitivity C-reactive protein (hs-CRP), angiotensin Ⅱ (Ang Ⅱ) and von Willebrand factor (vWF) in two groups were lower than those before treatment, and observation group was lower than that of control group, the differences were statistically significant (P < 0.05). Conclusion Yishen Qiangxin Decoction combined with Western medicine in treating DHF with syndrome of qi deficiency and blood stasis is more effective than Western medicine alone. It can improve cardiac function of patient, alleviate ventricular remodeling and reduce levels of inflammatory and vasoconstrictive factors, such as cTnI, hs-CRP, AngⅡ and vWF.
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