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| Research progress of itaconic acid in the diagnosis and treatment of inflammatory diseases |
| TANG Junpeng WEI Juanying LI Runqi ZOU Wei |
| Department of Neurology, Affiliated Nanhua Hospital, University of South China, Hu’nan Province, Hengyang 421001, China |
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Abstract Itaconic acid is mainly produced by macrophages in the human body, and it is a substance with extensive clinical application potential such as anti-inflammatory and antibacterial. Itaconic acid plays an important role in inflammation and immune diseases. The anti-inflammatory and antibacterial mechanisms of itaconic acid involve macrophage activation, polarization, generation of reactive oxygen species, metabolic reprogramming, immune regulation, Irg1 pathway, IκBζ inflammation parhrray etc. It has attracted widespread attention from scientists. Studies have found that blocking or increasing the production of itaconic acid can promote or inhibit the occurrence and development of diseases, but its mechanism in inflammation and antibacterial is not completely clear. Therefore, in-depth study of the role of itaconic acid in diseases is expected to provide reference for the application of itaconic acid in clinical drsease.
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