|
|
|
| Characteristics analysis of clinical researches on vagal nerve stimulation based on PubMed |
| ZHENG Jiayuan1,2 JIANG Jing3 QIAN Chenlei1,2 ZHUANG Yi2 LU Shengfeng1,2 |
| 1.Key Laboratory of Acupuncture and Medicine Research of Ministry of Education, Nanjing University of Chinese Medicine, Jiangsu Province, Nanjing 210023, China; 2.School of Acupuncture and Massage, School of Regimen and Rehabilitation, Nanjing University of Chinese Medicine, Jiangsu Province, Nanjing 210023, China; 3.Institute of Scientific and Technical Information of China, Beijing 100038, China |
|
|
|
Abstract Objective To analyze the clinical research literature of vagal nerve stimulation (VNS) in PubMed, summarize its research status and clinical characteristics, so as to provide reference for its research. Methods All literatures about VNS included in PubMed from January 1990 to June 2020 were retrieved, the co-occurrence analysis of authors, countries, institutions, journals and keywords were carried out by using CiteSpace software. Through information extraction and table drawing, the clinical characteristics of VNS, such as disease spectrum, therapeutic effect, stimulation mode and parameters were summarized and analyzed. Results A total of 138 literatures were included. The author who published the most articles was Zhu Bing; the top three countries were USA (75 articles), Germany (26 articles), Netherlands and UK (all 14 articles); the most published institutions were China Academy of Chinese Medical Sciences (7 articles), Electrocore (7 articles) and Minnesota University (7 articles). It was published in 78 journals, and the top two magazines were Epilepsia (11 articles) and Neurology (10 articles). The related research of VNS in the treatment of epilepsy and depression were research hotspot. The study involved 27 diseases, of which epilepsy, depression and migraine had the largest number; the main stimulation methods were implantable and percutaneous; and the main frequency of stimulation was low frequency, and the parameters depend on the disease and the mode of stimulation. Conclusion VNS has a good effect on neuropsychiatric diseases, especially epilepsy and depression. The research level of ear VNS is in the leading position in China. Non-implantable VNS will become a new research and development direction.
|
|
|
|
|
|
[1] 顾楠楠，李春波.经皮迷走神经刺激术研究进展[J].上海交通大学学报：医学版，2020，40（4）：539-542.
[2] Zabara J. Neuroinhibition of xylazine induced emesis [J]. Pharmacol Toxicol，1988，63（2）：70-74.
[3] Uthman BM，Wilder BJ，Hammond EJ，et al. Efficacy and safety of vagus nerve stimulation in patients with complex partial seizures [J]. Epilepsia，1990，31 Suppl 2：S44-S50.
[4] Degiorgio CM，Schachter SC，Handforth A，et al. Prospective long-term study of vagus nerve stimulation for the treatment of refractory seizures [J]. Epilepsia，2000，41（9）：1195-1200.
[5] Groves DA，Brown VJ. Vagal nerve stimulation：a review of its applications and potential mechanisms that mediate its clinical effects [J]. Neurosci Biobehav Rev，2005，29（3）：493-500.
[6] 龙盛荣，王越，袁彩虹，等.胶质瘤治疗热点的文献计量学分析[J].现代肿瘤医学，2019，27（15）：2665-2670.
[7] Bostr?觟m A，Scheele D，Stoffel-Wagner B，et al. Saliva molecular inflammatory profiling in female migraine patients responsive to adjunctive cervical non-invasive vagus nerve stimulation：the MOXY Study [J]. J Transl Med，2019，17（1）：53.
[8] 王晓宇，于清泉，何伟，等.从“分子药”到“电子药”：SPARC计划和针刺研究[J].针刺研究，2019，44（3）：157-160，175.
[9] De Ferrari GM，Crijns HJ，Borggrefe M，et al. Chronic vagus nerve stimulation：a new and promising therapeutic approach for chronic heart failure [J]. Eur Heart J，2011， 32（7）：847-855.
[10] Zannad F，De Ferrari GM，Tuinenburg AE，et al. Chronic vagal stimulation for the treatment of low ejection fraction heart failure：results of the Neural Cardiac Therapy for Heart Failure randomized controlled trial [J]. Eur Heart J，2015，36（7）：425-433.
[11] Clark KB，Naritoku DK，Smith DC，et al. Enhanced recognition memory following vagus nerve stimulation in human subjects [J]. Nat Neurosci，1999，2（1）：94-98.
[12] 俞裕天，荣培晶，朱兵.经皮耳迷走神经刺激治疗脑病的现状与展望[J].世界科学技术—中医药现代化，2017，19（3）：462-468.
[13] Round R，Litscher G，Bahr F. Auricular acupuncture with laser [J]. Evid Based Complement Alternat Med，2013，9（8）：984763.
[14] 孟凡刚，张建国.迷走神经刺激与癫痫的治疗[J].立体定向和功能性神经外科杂志，2009，22（3）：188-192.
[15] 魏天祺，冯珍.迷走神经电刺激临床应用及机制研究进展[J].中国康复医学杂志，2015，30（2）：185-188.
[16] 王大伟，周荣斌，姚咏明.胆碱能抗炎通路在炎症反应中的作用[J].生理科学进展，2010，41（3）：217-220.
[17] 卢圣锋，袁璟，丁亚娟，等.电针对大鼠缺血心肌组织中炎性物质和交感神经活性物质表达的影响[J].针刺研究，2019，44（5）：313-318.
[18] Hong GS，Pintea B，Lingohr P，et al. Effect of transcutaneous vagus nerve stimulation on muscle activity in the gastrointestinal tract（transVaGa）：a prospective clinical trial [J]. Int J Colorectal Dis，2019，34（3）：417-422.
[19] Koopman FA，Chavan SS，Miljko S，et al. Vagus nerve stimulation inhibits cytokine production and attenuates disease severity in rheumatoid arthritis [J]. Proc Natl Acad Sci U S A，2016，113（29）：8284-8289.
[20] 张涛，陈煜，李荣煌，等.电针预处理对急性心肌缺血小鼠心功能及免疫炎性反应的影响[J].中国针灸，2020， 40（6）：635-639.
[21] Merrill CA，Jonsson MA，Minthon L，et al. Vagus nerve stimulation in patients with Alzheimer’s disease：Additional follow-up results of a pilot study through 1 year [J]. J Clin Psychiatry，2006，67（8）：1171-1178.
[22] Fudim M，Qadri YJ，Ghadimi K，et al. Implications for Neuromodulation Therapy to Control Inflammation and Related Organ Dysfunction in COVID-19 [J]. J Cardiovasc Transl Res，2020，13（6）：894-899.
[23] Staats P，Giannakopoulos G，Blake J，et al. The Use of Non-invasive Vagus Nerve Stimulation to Treat Respiratory Symptoms Associated With COVID-19：A Theoretical Hypothesis and Early Clinical Experience [J]. Neuromodulation，2020，23（6）：784-788.
[24] 姜劲峰.体表刺激调节副交感的神经途径与效应[J].生理科学进展，2019，50（6）：401-406.
[25] 杨思琪，王继先，Mao L.新冠肺炎的神经系统表现[J].中国康复，2020，35（8）：432. |
|
|
|
