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Study on preparation technology and quality control of Jiawei Wuzi Yanzong Concentration Pills |
OU YANG Ruoshui1,2 ZHONG Lanying1 WEN Guiqing1 ZHONG Nijun1 ZHUO Jinsheng3 XING Yitao4 WANG Lisheng1 |
1.College of Traditional Chinese Medicine, Guangzhou University of Chinese Medicine, Guangdong Province, Guangzhou 510403, China;
2.Southern College of Pharmacy,Guangdong Jiangmen Chinese Medical College, Guangdong Province, Jiangmen 529000, China;
3.Department of Pulmonary Diseases, Hainan Provincial Hospital of Traditional Chinese Medicine, Hainan Province, Haikou 570203, China;
4.Department of Urinary Surgery, Hainan Provincial Hospital of Traditional Chinese Medicine, Hainan Province, Haikou 570203, China |
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Abstract Objective To establish a preparation method for Jiawei Wuzi Yanzong Concentration Pills and to test the quality of the concentration pills. Methods The concentration pills were prepared by plastic molded method. The formulation molding process was determined based on the soft material properties, moldability, moisture content and dissolution time limit, and the quality standard was tested according to the relevant requirements of Pharmacopoeia of the People’s Republic of China (2015 edition). Results The optimum forming process of Jiawei Wuzi Yanzong Concentration Pills was as follows: the relative density of thick paste was 1.40, the dosage ratio of medicine to honey was 1∶0.4, the powder fineness was 100 mesh, the drying temperature was 60℃ and the drying time was 10 h. The moisture content, dissolution time limit, weight difference and content of concentration pills were all in line with the regulations of Pharmacopoeia of the People’s Republic of China. Conclusion The molding process of concentration pills by this process is stable, reliable, simple and easy to operate, which provides a basis for industrial production.
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[1] 马敏怡,聂继红,张文兵,等.解毒祛痰浓缩丸成型工艺研究[J].亚太传统医药,2017,13(24):32-33.
[2] 詹文强,王炯,尚佳,等.杜仲腰痛浓缩丸制备工艺优化[J].中国实验方剂学杂志,2013,19(5):71-73.
[3] 徐晶晶,黄华花,林丽珍,等.缩泉浓缩丸制备工艺的优化[J].中医药导报,2019,25(19):63-65.
[4] 叶辉岩,马进原,毛景华,等.灵芝浓缩丸制备工艺研究[J].中国药业,2018,27(3):12-14.
[5] 肖绍玲,马燎原.浓缩六味地黄丸制备工艺的优化[J].中成药,2009,31(2):299-300.
[6] 黄华花,陈景海,王圣江.多指标综合评分法优选金山开胃丸的成型工艺[J].中医药导报,2019,25(8):52-55.
[7] 国家药典委员会.中华人民共和国药典(一部)[J].北京:中国医药科技出版社,2015.
[8] 张兆旺.中药药剂学[M].北京:中国中医药出版社,2007:327.
[9] 国家药典委员会.中华人民共和国药典(四部)[J].北京:中国医药科技出版社,2015.
[10] 杜宏伟.中药浓缩丸与水丸生产过程质量影响因素分析[J].中国药业,2011,20(22):54-55.
[11] 郭可锦.养寿丹浓缩丸的制备工艺及质量标准的研究[D].广州:广州中医药大学,2006.
[12] 俞旭君,董良,贾清树,等.五子衍宗丸浓缩丸治疗男性不育症(肾精亏损证)临床研究及不同剂型间疗效比较[J].内蒙古中医药,2019,38(11):9-11.
[13] 陆颖洁,梁惠芬,李小蝶,等.正交试验法优选左金浓缩丸成型工艺[J].中国药师,2018,21(3):389-392.
[14] 禹海燕,蔡成龙,杜庆伟,等.中药丸剂研究进展[J].药学研究,2019,38(7):424-426,430.
[15] 王银,李跃辉,蔡萍,等.二至丸成型工艺优化[J].国际药学研究杂志,2015,42(5):650-653.
[16] 罗仁书,何治勇.中药蜜丸的制备及质量控制[J].实用中医药杂志,2013,29(10):871-872.
[17] 韩苗苗,黑峥峥,华浩明.理中丸、肾气丸和六味地黄丸等方解不可缺蜜论[J].辽宁中医杂志,2018,45(6):1170-1172.
[18] 毛雪,赵鑫,郭艳.蜜丸的制备工艺及质量标准研究[J].检验医学与临床,2019,16(24):3710-3712.
[19] 林玉榕,郑丽燕.中药菟丝子药理研究[J].生物技术世界,2014(2):84.
[20] 王焕江,赵金娟,刘金贤,等.菟丝子的药理作用及其开发前景[J].中医药学报,2012,40(6):123-125.
[21] 宋晓钰,姜玉婷.菟丝子总黄酮的药理作用及其治疗痛经的研究[J].医学信息,2020,33(8):29-31.
[22] 夏卉芳,李啸红.菟丝子的药理研究进展[J].现代医药卫生,2012,28(3):402-403.
[23] 李锦松,陈剑鸿,孟民杰.金丝桃苷药理作用及其作用机制的研究进展[J].广东药学院学报,2015,31(2):269-272.
[24] 杨诗婷,王晓倩,廖广辉.金丝桃苷的药理作用机制研究进展[J].中国现代应用药学,2018,35(6):947-951.
[25] 王长鹰,李军.金丝桃苷对严重烧伤大鼠的心肌保护作用及机制[J].山西医科大学学报,2019,50(12):1718-1724. |
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