补脾胃泻阴火升阳汤治疗脾虚胃热型失眠的临床效果

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Abstract Objective To observe clinical effect of Bupiwei Xieyinhuo Shengyang Decoction in the treatment of insomnia characterized by spleen deficiency and stomach heat and its influence on sleep quality and inflammatory factors. Methods From December 2017 to March 2019, 60 cases of insomnia patients with syndrome of spleen deficiency and stomach heat were recruited in Guangdong Provincial Hospital of Traditional Chinese Medicine, and they were divided into control group and experimental group according to random number table method, with 30 cases in each group. Thirteen cases fell off in control group, three cases fell off in experimental group, with 17 cases in control group and 27 cases in experimental group finally. Control group was given the simulation agent, and experimental group was given Bupiwei Xieyinhuo Shengyang Decoction, the total course of treatment was four weeks. Pittsburgh sleep quality index (PSQI), insomnia severity index (ISI), serum cortisol (CORT) and cytokines [interleukin-1β (IL-1β), tumor necrosis factor-α (TNF-α), tumor necrosis factor-β (TNF-β), interleukin-10 (IL-10), interferon-α (IFN-α)] levels of two groups were observed before and after treatment. Results Total scores of PSQI and ISI in two groups after treatment were lower than those before treatment (P < 0.05). The levels of serum IL-1β and TNF-α in experimental group were higher than those before treatment (P < 0.05). The level of serum IL-10 in experimental group was higher than that before treatment (P < 0.05). The level of serum IFN-α in control group was lower than that before treatment (P < 0.05). After treatment, the serum IFN-α level in experimental group was higher than that in control group (P < 0.05). There were no serious adverse events in this study. There were two mild adverse events. Conclusion Bupiwei Xieyinhuo Shengyang Decoction can significantly improve the subjective sleep quality of insomnia with syndrome of spleen deficiency and stomach heat, improve immunity and regulate the inflammatory status.

Key words： Insomnia Spleen deficiency and stomach heat Bupiwei Xieyinhuo Shengyang Decoction Cytokines Inflammation

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	XIAO Rong1 ZHAO Chunyi1 ZHENG Liming2 YANG Lingling2 LI Yan2

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XIAO Rong1 ZHAO Chunyi1 ZHENG Liming2 YANG Lingling2 LI Yan2. Clinical effect of Bupiwei Xieyinhuo Shengyang Decoction in the treatment of insomnia with syndrome of spleen deficiency and stomach heat[J]. 中国医药导报, 2020, 17(33): 137-140.

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http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2020/V17/I33/137

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