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| Correlation between total bile acid level and fetal distress in patients with intrahepatic cholestasis of pregnancy |
| ZHOU Liqin1 CHEN Jie2 WU Hui1 WANG Zhihui1▲ |
1.Department of Obstetrics and Gynecology, Xiangcheng People’s Hospital of Suzhou City, Jiangsu Province, Suzhou 215131, China;
2.Department of Obstetrics and Gynecology, the First Affiliated Hospital of Soochow University, Jiangsu Province, Suzhou 215006, China |
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Abstract Objective To explore the correlation between the serum total bile acid (TBA) level and fetal distress in intrahepatic cholestasis of pregnancy (ICP). Methods Eighty-seven cases of ICP pregnant women admitted to Department of Obstetrics and Gynecology of Xiangcheng People’s Hospital of Suzhou from July 2014 to June 2019 were selected as research objects. According to the serum TBA level, they were divided into mild ICP group (57 cases, serum TBA 10.00-<40.00 μmol/L) and severe ICP group (30 cases, TBA ≥ 40.00 μmol/L). Another 38 healthy pregnant women were selected as control group. The levels of serum TBA, gamma-glutamyl transpeptidase (GGT), aspartate aminotransferase (AST), alanine aminotransferase (ALT) and cholyglycine (CG) and the occurrence of fetal distress were compared among three groups. The correlation between serum TBA level and liver function indexes of ICP pregnant women was observed, and the correlation between TBA and fetal distress in ICP pregnant women was analyzed. Results The levels of TBA, AST, ALT, GGT and CG in mild ICP group and severe ICP group were higher than those in normal control group (P < 0.05), and the above indexes in mild ICP group were lower than those in severe ICP group (P < 0.05). There was no correlation between serum TBA and AST, ALT, GGT, GC (P > 0.05). There was significant difference in the incidence of fetal distress among three groups (P < 0.05). The critical value of serum TBA in predicting fetal distress was 38.600 μmol/L, the area under ROC curve was 0.792, and the progressive P value was 0.002. The difference of serum TBA in predicting fetal distress was statistically significant (P < 0.05). Conclusion Serum TBA can damage the liver function of pregnant women. The level of TBA is closely related to the risk of fetal distress in ICP pregnant women, which provides reference for clinical treatment and disease judgment.
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