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| Research progress of renal injury molecule-1 and renal diseases |
| ZHAO Ning ZHU Guozhen |
| Department of Nephrology, the Second Hospital of Shanxi Medical University， Shanxi Province, Taiyuan 030001, China |
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Abstract In recent years, the prevalence of renal diseases has increased year by year. Early detection and early intervention of renal injury is the key to avoid further deterioration of renal function. Therefore, it is particularly important to find a biomarker that can early reflect renal injury. Kidney injury molecule-1 (KIM-1) is a type Ⅰ membrane protein, and expression increases rapidly during kidney injury, and its level increases with the degree of kidney injury. KIM-1 may play a role in the process of renal repair and injury through different molecular sites. KIM-1 in urine and blood are associated with various causes of acute renal injury, chronic renal disease, IgA nephropathy, henoch-schonlein purpura kidney and renal tumor. KIM-1 is not only an early biomarker of renal injury, but also has a potential role in predicting renal prognosis. This article reviews the research progress of KIM-1 and renal diseases.
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