利妥昔单抗治疗难治性原发免疫性血小板减少症的研究进展

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Abstract Primary immunologic thrombocytopenic purpura (ITP) is a hemorrhagic disease caused by immune-mediated acquired thrombocytopenia, and it is called refractory ITP if ITP is still confirmed as ITP after diagnosis and reassessment, ineffective ITP with splenectomy or postoperative recurrence. Due to the complicated pathogenesis, there is currently no unified treatment plan for clinically refractory ITP. Rituximab has a good therapeutic effect on ITP by killing abnormal B lymphocytes and alleviating platelet destruction. This article reviews the mechanism of action, clinical program, and efficacy of Rituximab in the treatment of refractory ITP, with a view to promoting further research of Rituximab in the treatment of refractory ITP.

Key words： Primary immunologic thrombocytopenic purpura Refractory Rituximab Review

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	HUANG Ziming LI Ruibai HOU Li ZHANG Yayue

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HUANG Ziming LI Ruibai HOU Li ZHANG Yayue. Research progress of Rituximab in the treatment of refractory primary immunologic thrombocytopenic purpura[J]. 中国医药导报, 2020, 17(33): 38-41.

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http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2020/V17/I33/38

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