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| Correlation study between sarcopenia and osteoporosis in postmenopausal female |
| MIAO Ketuan1 XU Bing2 WANG Xiaofeng2▲ WANG Guanhua2 XUE Yangyang3 LIN Zongzhuang4 |
1.Graduate School, Anhui University of Chinese Medicine, Anhui Province, Hefei 230000, China;
2.Department of Orthopedics, Wenzhou Hospital of Integrated Traditional Chinese and Western Medicine, Zhejiang Chinese Medical University, Zhejiang Province, Wenzhou 325000, China;
3.Department of Bone Density, Wenzhou Hospital of Integrated Traditional Chinese and Western Medicine, Zhejiang Chinese Medical University, Zhejiang Province, Wenzhou 325000, China;
4.Department of Traditional Chinese Medcine, Wenzhou Hospital of Integrated Traditional Chinese and Western Medicine, Zhejiang Chinese Medical University, Zhejiang Province, Wenzhou 325000, China |
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Abstract Objective To investigate the correlation between sarcopenia and osteoporosis (OP) in postmenopausal female. Methods A total of 117 postmenopausal female volunteers over 45 years old who attended Wenzhou Hospital of Integrated Traditional Chinese and Western Medicine Affiliated to Zhejiang Chinese Medical University were selected from January to December 2018. According to the bone mineral density (BMD), they were divided into OP group and non-OP group (Non-OP group). The general condition of the patients were recorded. A dual-energy X-ray absorptiometer was used to measure the BMD of the L1-4 lumbar and hips, the appendicular skeletal muscle mass (ASM), and the appendicular fat mass (AFM), as well as the muscle strength and walk velocity. The appendicular skeletal muscle mass index (ASMI) was calculated. Linear correlation analysis was used to analyze the correlation between ASM, AFM, ASMI and BMD, and logistic regression analysis was used to analyze the correlation between sarcopenia and OP. Results The BMD of L1-4 lumbar was positively correlated with ASM, ASMI, walk velocity, muscle strength and body mass index (r = 0.487, 0.361, 0.468, 0.287, 0.368, all P ＜ 0.05). The BMD of hip was positively correlated with ASM, ASMI, walk velocity, muscle strength and body mass index (r = 0.377, 0.345, 0.370, 0.276, 0.380, all P ＜ 0.05). There were no significant correlation between the BMD of L1-4 lumbar and hip with AFM (all P ＞ 0.05). There were 16 patients with sarcopenia (13.7%). Logistic regression analysis showed that sarcopenia was a risk factor for osteoporosis (P < 0.05). Conclusion BMD is closely related to sarcopenia in postmenopausal women. BMD is positively correlated with ASM, muscle strength and walk velocity but not with AFM. The incidence of sarcopenia increases significantly with the decrease of BMD and the increase of age.
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