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| Effect of acupoint application of Bushen Gutai Cream on serum sex hormone levels and cytokines in early threatened abortion patients with kidney deficiency |
| ZHENG Na WANG Ting YANG Lijuan |
| Department of Gynecology, Yunnan Provincial Hospital of Traditional Chinese Medicine, Yunnan Province, Kunming, 650021, China |
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Abstract Objective To observe the effect of acupoint application of Bushen Gutai Cream on serum sex hormone levels and cytokines in early threatened abortion patients with kidney deficiency. Methods A total of 74 pregnant women diagnosed as early threatened abortion with kidney deficiency were selected from Department of Gynecology, Yunnan Provincial Hospital of Traditional Chinese Medicine from January 2017 to December 2018. According to the order in which the patient was treated, the patients were sorted from one, and then according to the random number table, the patients were divided into the observation group and the control group with 37 cases each. The control group was given progesterone injection of 40 mg intramuscular injection plus Shoutai Wan orally. On this basis, the observation group was given Bushen Gutai Cream applied to shenque point for treatment. After two weeks of treatment, the improvement of the traditional Chinese medicine symptom scores in the two groups, the patients′ hormone levels, expression of cytokines in T-helper 1 cells (Th1) and T-helper 2 cells (Th2) were observed, and safety evaluation was performed. Results After two weeks of treatment, the scores of traditional Chinese medicine symptoms in the observation group were significantly lower than those in the control group (all P ＜ 0.01). The hormone levels of the observation group were significantly higher than those of the control group (P ＜ 0.01), the levels of cytokines in Th1 were lower than those of the control group, and the levels of cytokines in Th2 were higher than those of the control group (P ＜ 0.01). No obvious adverse reactions occurred in both groups. Conclusion Acupoint application of Bushen Gutai Cream can significantly increase the hormone level of patients, improve the imbalance of cytokines, relieve clinical symptoms, which is safe and effective.
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