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| Effect of low dose Atorvastatin Calcium combined with Amlodipine Besylate on elderly patients with hypertension |
| LU Xin1 ZHAO Guifeng2▲ |
1.Department of Cardiovascular Medicine, Rocket Army Characteristic Medical Center， Beijing 100088, China;
2.Department of Critical Medicine, Rocket Army Characteristic Medical Center, Beijing 100088, China |
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Abstract Objective To investigate the effect of low dose Atorvastatin Calcium combined with Amlodipine Besylate on elderly patients with hypertension. Methods From January 2016 to June 2019, 180 elderly patients with hypertension admitted to Rocket Army Characteristic Medical Center were selected and they were divided into the control group (90 cases) and the combined treatment group (90 cases) according to the random number table method. The control group was given Amlodipine Besylate orally and the combined treatment group was given Amlodipine Besylate+Atorvastatin Calcium orally. The changes of blood pressure, blood lipid and inflammatory factors between the two groups were compared. Results The average systolic blood pressure, average diastolic blood pressure, total cholesterol, triglyceride, low-density lipoprotein cholesterol, apolipoprotein a, homocysteine, high-sensitivity C-reactive protein, angiotensin Ⅱ levels after one, three months of treatment in the combined treatment group were lower than those in the control group, while high-density lipoprotein cholesterol level was higher than that of the control group (all P < 0.01). Conclusion The effect of adding low dose Atorvastatin Calcium on reducing blood pressure, blood lipid and inflammatory factors in patients with hypertension is significantly better than that of simple antihypertensive drug therapy, and low dose Atorvastatin Calcium and antihypertensive drugs have synergistic antihypertensive effect.
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