组织多普勒心肌综合指数联合血浆脑钠肽检测评价肝硬化失代偿期患者心功能的临床研究

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Abstract Objective To evaluate the cardiac function in patients with decompensated cirrhosis by tissue Doppler myocardial performance index (Tei index) combined with plasma B-type natriuretic peptide (BNP). Methods A total of 100 patients with cirrhosis diagnosed and hospitalized in the Department of Gastroenterology, the First Affiliated Hospital of Hebei North University (“our hospital” for short) from June 2014 to June 2016 were selected, and they were divided into the compensated cirrhosis group and the decompensated cirrhosis group according to Child-Pugh grading of liver function and clinical symptoms, with 50 cases in each group. In addition, 40 healthy people who underwent physical examination in our hospital during the same period were selected as the normal control group. Tei index, plasma BNP level and liver function indexes among three groups were compared. The correlation between left and right ventricular Tei indexes and plasma BNP levels in patients with decompensated cirrhosis in different grading were analyzed. Tei index and plasma BNP levels of patients with decompensated cirrhosis in different grading were compared. Results The levels of alanine aminotransferase and aspartate aminotransferase in the decompensated cirrhosis group were higher than those in the normal control group, the levels of total bilirubin (TBil) were higher than those in the normal control group and the compensated cirrhosis group, and the levels of albumin (ALB) were lower than those in the normal control group and the compensated cirrhosis group; the levels of TBil in the compensated cirrhosis group were higher than those in the normal control group and the levels of ALB in the compensated cirrhosis group were lower than those in the normal control group (all P < 0.05). Left and right ventricle Tei indexes and BNP levels in the decompensated cirrhosis group were higher than those in the normal control group and the compensated cirrhosis group; left and right ventricle Tei indexes and BNP levels of in the compensated cirrhosis group were higher than those in the normal control group (all P < 0.05). Left and right ventricular Tei indexes were positively correlated with plasma BNP level in patients with decompensated cirrhosis (r = 0.717, 0.618, all P < 0.01). Left and right ventricular Tei indexes and plasma BNP levels in patients with grade C decompensated cirrhosis were higher than those in patients with grade B decompensated cirrhosis (all P < 0.05). Conclusion Tei index and plasma BNP level were significantly correlated with cardiac function in patients with decompensated cirrhosis, and the combination can quantitatively evaluate the decompensated stage of cirrhosis.

Key words： Myocardial composite index Plasma B-type natriuretic peptide Cirrhosis Decompensation period Cardiac function Correlation

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	CHEN Xi WANG Likun WANG Yicheng

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CHEN Xi WANG Likun WANG Yicheng. Clinical study on the evaluation of cardiac function in patients with decompensated cirrhosis by tissue Doppler myocardial composite index and plasma B-type natriuretic peptide[J]. 中国医药导报, 2020, 17(29): 65-68.

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http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2020/V17/I29/65

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