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| Effect of BAL on bronchiectasia with infection and its effects on blood gas and serum inflammatory factors |
| Miriguli·Yilihamu LU Yao WANG Hui Sawuti·Tuerdi |
| Respiratory Medicine, the First People′s Hospital of Aksu, Xinjiang Uygur Autonomous Region, Aksu 843000, China |
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Abstract Objective To investigate the effect of bronchoalveolar lavage (BAL) on bronchiectasia(BE) with infection and its influence on the levers of blood gas indexes and serum inflammatory indexes. Methods From January 2015 to December 2016, 120 patients came from the First People′s Hospital of Aksu for treatment of BE with infection were selected as the study object. They were divided into groups by random number table. 60 patients of control group were treated with basic treatment measures, 60 patients of treatment group were treated with BAL under fiberoptic bronchoscope on the basis treatment of the control group. The blood gas indexes and serum inflammatory indexes of the two groups were measured before and after treatment, and the clinical efficacy was evaluated at the end of the course. The blood gas index, serum inflammatory index and clinical effective rate were compared between the two groups before and after treatment. Results Before treatment, the levels of arterial partial pressure of oxygen (PaO2), arterial partial pressure of carbon dioxide (PaCO2) and ]oxygenation index (PaO2/FiO2) in the two groups were not statistically significant (P > 0.05); after treatment, the levels of PaO2 and PaO2/FiO2 in the treatment group were higher than those in the control group (P < 0.05), and PaCO2 was lower than that in the control group (P < 0.05). Before treatment, the levels of TNF-α, Hypersensitivity C reactive protein (hs-CRP), Interleukin -2 (IL-2), IL-4, IL-23 and transforming growth factor-β (TGF-β) in the treatment group and the control group were not statistically significant (P > 0.05); After treatment, the level of IL-2 in the treatment group was higher than that in the control group (P < 0.05), and the levels of TNF-α, hs-CRP, IL-4, IL-23 and TGF-β in the treatment group were lower than those in the control group (P < 0.05). After treatment, the effective rate of the treatment group was 58.33%, which was higher than control group 41.67% (P < 0.05). Conclusion Serum inflammatory factor levels and blood gas level of BE and infection can be improved after BAL treatment, it is worthy of clinical application.
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