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| Research on the formula features and academic thoughts of Jingyue Quanshu·Furen Gui for treating menopathy diseases |
| QIAN Xuwu1 JIANG Yuchen1 ZHAO Qi2 JIANG Ying2 |
1.College of Traditional Chinese Medicine, Zhejiang Pharmaceutical College, Zhejiang Province, Ningbo 315503, China;
2.Department of Gynecology, Ningbo Hospital of Traditional Chinese Medicine, Zhejiang Province, Ningbo 315503, China |
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Abstract Objective To systemically sort out the prescriptions for the treatment of menopathy diseases in “Jingmai Lei” in the Jingyue Quanshu·Furen Gui, and to explore his academic thoughts. Methods Taking the book of Jingyue Quanshu·Furen Gui published by China Medical Science Press as the retrieval source, the formulas that met the inclusion criteria were used for frequency analysis. The software of SPSS Statistic 23.0 and SPSS Modeler 14.1 were used for cluster analysis and association analysis of the high frequency drugs. Results Finally, 97 prescriptions were obtained, of which, the tonifying array was the most. A total of 100 Chinese herbs were obtained, among which, the high frequency drugs included Radix Angelicae Sinensis, Radix Glycyrrhizae, Radix Rehmanniae Preparata, and so on. Five core drug groups were obtained by cluster analysis, which were Radix Ginseng and Radix Glycyrrhizae, Rhizoma Ligustici Chuanxiong and Chinese peony, Cortex Moutan Radicis and Rhizoma Alismatis, Radix Bupleuri and Pericarpium Citri Reticulatae, Rhizoma Dioscoreae and Fructus Corni. Through correlation analysis, four drug combinations with strong correlation were obtained, which were Radix Glycyrrhizae and Radix Ginseng, Radix Angelicae Sinensis and Radix Glycyrrhizae, Radix Angelicae Sinensis and Chinese peony, Radix Angelicae Sinensis and Radix Rehmanniae Preparata. According to Apriori correlation analysis model, eight groups of traditional Chinese medicine with potential association rules, which were Radix Glycyrrhizae and Radix Ginseng, Radix Glycyrrhizae and Rhizoma Atractylodis Macrocephalae, Radix Rehmanniae Preparata and Rhizoma Dioscoreae, Radix Angelicae Sinensis and Rhizoma Ligustici Chuanxion, Radix Glycyrrhizae and Radix Bupleuri, Rhizoma Dioscoreae and Fructus Corni, Radix Rehmanniae Preparata and Fructus Corni, Radix Glycyrrhizae and Rhizoma Zingiberis. Conclusion The results of data mining show that Zhang Jingyue is good at replenishing qi and nourishing blood, especially in invigorating spleen and tonifying kidney, and strengthening vital qi and eliminating pathogen in the same time, and paying attention in warming up but not eliminating heat. The result of data mining is consistent with the traditional theory, which is reasonable and effective.
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