野百合碱诱导肺动脉高压模型的机制研究及潜在临床应用价值进展

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Abstract Pulmonary artery hypertension (PAH) is a fatal cardiovascular disease characterized by increases in pulmonary artery pressure and pulmonary vascular resistance. The pathological features of PAH induced by monocrotaline (MCT) are similar to those of clinical patients. MCT-induced PAH through multiple factors including inflammatory response, endothelium pathway, and regulation of pulmonary artery smooth muscle cells proliferation, et al. Therefore, this article briefly reviews the advances molecular mechanism of the MCT-induced PAH and the exploration in the novel therapeutic targets by using this animal model in recent years.

Key words： Pulmonary arterial hypertension Monocrotaline Signal pathway Drug target

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	CHENG Xiaohan1 QI Jing2 BAI Yuhua1 ZHENG Xiaodong2

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CHENG Xiaohan1 QI Jing2 BAI Yuhua1 ZHENG Xiaodong2. Advanced mechanisms and potential clinical application value of monocrotaline-induced pulmonary artery hypertension animal model[J]. 中国医药导报, 2020, 17(27): 40-43.

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http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2020/V17/I27/40

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