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| Expression of UBQLN-1 and RUNX3 in rectal cancer tissues and their clinical significance |
| SUN Guangyuan1 GUO Shengchao2 WU Xueliang1 XUE Jun1 QU Ming1 GUO Fei1 HAN Lei1 HAN Jie3 |
1.Department of General Surgery, the First Affiliated Hospital of Hebei North University, Hebei Province, Zhangjiakou 075061, China;
2.Graduate School, Hebei North University, Hebei Province, Zhangjiakou 075061, China;
3.Department of Ophtalmology, the Fourth Hospital of Zhangjiakou, Hebei Province, Zhangjiakou 075061, China |
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Abstract Objective To explore the expression of UBQLN-1 and RUNX3 in rectal cancer tissues and clinical significance. Methods From June 2017 to June 2019, 85 cases of rectal cancer tissues and adjacent normal tissues were selected from the First Affiliated Hospital of Hebei North University were selected. The mRNA and protein levels of UBQLN-1 and RUNX3 were detected by reverse transcription polymerase chain reaction (RT-PCR) and immunohistochemistry and the relationship between UBQLN-1, RUNX3 and the clinicopathological characteristics of tumors and the correlation between their expressions were analyzed. Results The expression of UBQLN-1 mRNA in rectal cancer tissues was higher than that in adjacent normal tissues; and the expression of RUNX3 mRNA in rectal cancer tissues was lower than that in adjacent normal tissues，and the differences were highly statistically significant (P ＜ 0.01). The positive expression rate of UBQLN-1 in rectal cancer tissues was higher than that in adjacent normal tissues and the positive expression rate of RUNX3 was lower than that of adjacent normal tissues, with highly statistically significant differences (P < 0.01). UBQLN-1 was negatively correlated with RUNX3 expression in rectal cancer tissues（r = -0.225, P = 0.038）. Conclusion The abnormal expressions of UBQLN-1 and RUNX3 in the rectal cancer tissues are closely related to their development and evolution, and rectal cancer tissues and adjacent normal tissues are significantly negatively correlated, which can be used as potential molecular biological indicators for the diagnosis, treatment and prognosis assessment of rectal cancer.
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