补肾法对颈动脉粥样硬化患者脂代谢的影响

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Abstract Objective To evaluate the effect of kidney-tonifying method on lipid metabolism in elderly patients with carotid atherosclerosis (CAS). Methods One hundred and twenty-two CAS patients with syndrome of deficiency of kidney essence from January 2015 to July 2016 in Longhua Hospital of Shanghai University of Traditional Chinese Medicine were randomly divided into control group and treatment group by random number table method, with 61 cases in each group. The control group was treated with Simvastatin Tablets, the treatment group was treated with Yishen Oral Liquid. The treatment duration of both groups was 24 weeks. The traditional Chinese medicine (TCM) syndrome scores of both groups were evaluated and compared before and after treatment, and the levels of the blood lipid indexes (triacylglycerol [TG], total cholesterol [TC], low density lipoprotein cholesterol [LDL-C] and high density lipoprotein cholesterol [HDL-C]) were detected． At the same time, the adverse reactions were observed. Results In the control group, three cases fell off with 58 cases completed and in the treatment group, four cases fell off with 57 cases completed, 115 cases were involved in statistical analysis. There was no significant difference of the total TCM syndrome scores in the control group before and after treatment (P ＞ 0.05). After treatment, the total TCM syndrome score in the treatment group was lower than that before treatment (P ＜ 0.05), and lower than that in the control group (P ＜ 0.05); after treatment, the efficacy of TCM syndrome in the treatment group was better than that in the control group (P ＜ 0.05). After treatment, the HDL-C level in the control group was lower than before treatment (P ＜ 0.05), the HDL-C level in the treatment group was higher than before treatment (P ＜ 0.05), and higher than that in the control group (P ＜ 0.05). After treatment, the TC levels in both groups were lower than that before treatment (P ＜ 0.05), and the TC level in treatment group was higher than that in control group (P ＜ 0.05). Before and after treatment, there were no significant differences in adverse reactions between the two groups (P ＞ 0.05). Conclusion Yishen Oral Liquid can regulate blood lipid metabolism and reduce cholesterol in patients with CAS, and it has significant advantages compared with the control group in terms of increasing HDL-C level. It can effectively improve TCM syndromes with no obvious adverse reactions.

Key words： Carotid atherosclerosis Kidney-tonifying method Yishen Oral Liquid Blood lipid Traditional Chinese medicine syndrome scores

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	SUN Weihua GU Yun GAO Shuang

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SUN Weihua GU Yun GAO Shuang. Effect of kidney-tonifying method on lipid metabolism in patients with carotid atherosclerosis[J]. 中国医药导报, 2020, 17(26): 134-138.

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http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2020/V17/I26/134

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