斡旋中州方治疗肥胖型多囊卵巢综合征伴胰岛素抵抗的前瞻性临床观察

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Abstract Objective To explore the clinical effect and security of the empirical formula of Professor Wang Guohua, Mediation of Zhongzhou Prescription, in the treatment of obese polycystic ovary syndrome (PCOS) with insulin resistance. Methods A total of 59 PCOS patients with insulin resistance and obesity with syndrome of phlegm-dampness due to spleen deficiency in the Gynecology Department of the Third Affiliated Hospital of Beijing University of Chinese Medicine from September 2016 to March 2018 were selected as the research subjects. Patients were divided into control group (29 cases) and experimental group (30 cases) according to the random number table method. Metformin Tablets were taken orally in the control group, Mediation of Zhongzhou Prescription were taken orally in the experimental group. Basal body temperature (BBT) was recorded daily during treatment. Body mass index (BMI), waist-to-hip ratio (WHR), homeostasis model assessment-insulin resistance (HOMA-IR) and testosterone (T), luteinizing hormone/follicle-stimulating hormone (LH/FSH) were measured before and after treatment. The clinical efficacy of the two groups was compared before and after treatment, and the occurrence of adverse reactions was observed. Results After treatment, the total effective rate of clinical syndromes in the experimental group was higher than that in the control group (P ＜ 0.05). Before treatment, there were no significant differences in WHR, BMI, HOMA-IR indexes and sex hormone (T, LH and FSH) levels between the two groups (P ＞ 0.05). After treatment, in the experimental group, the levels of WHR, BMI, HOMA-IR and LH/FSH were significantly lower than before treatment (P ＜ 0.05), in the control group, the levels of BMI and HOMA-IR were significantly lower than before treatment (P ＜ 0.05), and LH/FSH in the experimental group was lower than that in the control group (P ＜ 0.05). There were four cases of gastrointestinal reactions in control group, while no obvious adverse reactions occurred in treatment group. Conclusion Professor Wang Guohua′s empirical formula in the treatment of obese PCOS with insulin resistance has significant effect and certain clinical application value, which is worthy of promotion, application and further research.

Key words： Mediation of Zhongzhou Prescription Obesity Polycystic ovary syndrome Insulin resistance Syndrome of phlegm-dampness due to spleen deficiency

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	PANG Ying1 LIU Jinfeng2 JIANG Zixi3 LIU Yuxin3 TANG Lei3 ZHU Xiujuan3 WANG Guohua3 LIU Yanfeng1

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PANG Ying1 LIU Jinfeng2 JIANG Zixi3 LIU Yuxin3 TANG Lei3 ZHU Xiujuan3 WANG Guohua3 LIU Yanfeng1. Prospective clinical observation of Mediation of Zhongzhou Prescription in the treatment of obese polycystic ovary syndrome with insulin resistance[J]. 中国医药导报, 2020, 17(26): 124-128.

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http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2020/V17/I26/124

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