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| Changes of serum sTfR level in children with HbH disease and its clinical significance |
| LAI Meimei YU Xia LIAO Zhiyong SHEN Wei LIU Chenggui |
| Department of Laboratory, Women and Children′s Hospital Affiliated to Medical College of Electronic Science and Technology University Chengdu Women′s and Children′s Central Hospital, Sichuan Province, Chengdu 610091, China |
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Abstract Objective To study the expression of soluble transferrin receptor (sTfR) in the serum of children with hemoglobin H (HbH) disease and its clinical significance. Methods From January 2017 to September 2018, 79 patients with HbH disease who diagnosed and treated in Women and Children′s Hospital Affiliated to Medical College of Electronic Science and Technology University (“our hospital” for short) were selected as case group, and they were divided into non-deletion group (26 cases) and deletion group (53 cases) according to the genotype test results. A total of 40 healthy children in our hospital during the same period were selected as control group. The sTfR, hemoglobin (Hb), mean corpuscular hemoglobin (MCH), red blood cell (RBC), mean corpuscular volume (MCV) and serum ferritin level berween three groups were statistically analyzed and the correlation between serum sTfR level and hematological indexes in children with HbH disease were analyzed. Results In case group, deletion type (-α3.7/--SEA, -α4.2/--SEA) accounted for 67.1%, non-deletion type (αCSα/--SEA, αQSα/--SEA, αΔ30α/--SEA) accounted for 32.9%. The serum levels of sTfR and SF in deletion group and non-deletion group were higher than those in control group, while the levels of Hb, RBC, MCH and MCV were lower than those in control group, with statistically significant differences (all P < 0.05). The serum levels of sTfR, MCH, MCV and SF in non-deletion group were higher than those in deletion group, while the levels of Hb and RBC were lower than those in deletion group, with statistically significant differences (all P < 0.05). In case group, the serum sTfR level was significantly positively correlated with serum MCH, MCV and SF (r = 0.621, 0.734, 0.521, P < 0.05), but negatively correlated with RBC and Hb (r = -0.721, -0.675, P < 0.05). Conclusion Serum level of sTfR is related to the severity of anemia and iron metabolism in children with HbH disease, which may be a serological indicator of the disease.
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