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| Observation of preoperative oral rehydration salts combined with magnesium sulfate on C-reactive protein, GFV and prognosis of elderly breast cancer patients undergoing radical mastectomy |
| ZI Congna FAN Juan XING Zhen |
| Department of Anesthesiology, the First Affiliated Hospital of Hebei North University, Hebei Province, Zhangjiakou 075000, China |
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Abstract Objective To investigate the effect of preoperative oral rehydration salts combined with magnesium sulfate on C-reactive protein (CPR) and residual gastric fluid volume (GFV) and prognosis in elderly breast cancer patients undergoing radical mastectomy. Methods Eighty patients undergoing radical mastectomy in the First Affiliated Hospital of Hebei North University from November 2018 to April 2019 were selected and divided into the combined group and the magnesium sulfate solution group according to the random number table method, with 40 cases in each group. In the magnesium sulfate solution group, 50 mL of 25% magnesium sulfate solution was taken orally at 15∶00 one day before operation. The combined group was given 50 mL of oral 25% magnesium sulfate solution at 15∶00 on one day before operation and oral rehydration salt at 17∶00, dissolved in 300 mL warm water, and was taken within one hour. The levels of CRP at 8∶00 on one day before operation (T1) and fasting at 8:00 on the day of operation (T2) were calculated, as well as GFV at 14∶00 on one day before operation (T3) and 23∶00 on one day before operation (T4). The times of defecation, postoperative exhaust time and postoperative hospital stay of the two groups were counted from 8∶00 on the day of operation after magnesium sulfate solution was given. Visual analogue scales (VAS) was used to calculate the VAS scores of the two groups at the room resting state (T5), immediately after surgery (T6) and one day affer surgery (T7). The occurrence of postoperative adverse reactions was compared between the two groups. Results Compared with T1 time point, the levels of CRP were decreased in both groups at T2 time point, and the combined group was lower than that in the magnesium sulfate solution group at T2 time point, the differences were highly statistically significant (all P ＜ 0.01). Compared with T3 time point, GFV in both groups was reduced at T4 time point, and the combined group was lower than magnesium sulfate solution group at T4 time point, the differences were highly statistically significant (all P ＜ 0.01). The times of defecation in the combined group was higher than that in the magnesium sulfate solution group, and the postoperative exhaust time and postoperative hospital stay were shorter than those in the magnesium sulfate solution group, and postoperative adverse reactions were lower than that in the magnesium sulfate solution group, with statistically significant differences (all P ＜ 0.05). VAS score in T7 of the combined group was lower than that of the magnesium sulfate solution group, and the difference was statistically significant (P ＜ 0.05). Conclusion Preoperative oral rehydration salts combined with magnesium sulfate can reduce the preoperative the levels of CRP and GFV in elderly breast cancer patients and reduce the incidence of postoperative adverse reactions, which is worthy of clinical application.
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