加味冰硼散漱口液含漱对头颈癌放疗患者免疫功能的影响

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Abstract Objective To observe the effect of Modified Bingpeng Power Mouthwash on immune function of patients with head and neck cancer radiotherapy. Methods A total of 98 eligible head and neck cancer radiotherapy patients admitted to the Department of Radiotherapy, Gansu Provincial Cancer Hospital from October 2017 to December 2018 were divided into the traditional Chinese medicine group and the Western medicine group according to the order of admission and the random number table method. Among them, 12 patients fell off in the test, and 43 patients in the traditional Chinese medicine group and the Western medicine group were included in the statistics. From the first day of radiotherapy to the end of radiotherapy, the traditional Chinese medicine group was given the gargle of Modified Bingpeng Power Mouthwash and the Western medicine group was given the conventional Western medicine gargle. Flow cytometry was used to detect CD3+, CD4+, CD8+ and CD4+/CD8+ subsets of T lymphocytes in the two groups before and after radiotherapy, and they were compared. Results After treatment, CD4+ and CD4+/CD8+ in both groups were lower than before treatment, and the Western medicine group was lower than the traditional Chinese medicine group, with statistically significant differences (P ＜ 0.05). There were no significant differences in CD3+ and CD8+ of the two groups before and after treatment (P ＞ 0.05). Conclusion Radiotherapy of head and neck tumors can damage the cellular immune function of patients, resulting in the decrease of CD4+ and CD4+/CD8+ values in T cell subsets. Modified Bingpeng Power Mouthwash can reduce the decrease of CD4+ and CD4+/CD8+ values in T cell subsets caused by radiotherapy.

Key words： Modified Bingpeng Power Mouthwash Head and neck malignant tumor Immune Function T cell subset

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	WANG Zhaojun1 GAO Liying2

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WANG Zhaojun1 GAO Liying2. Effect of Modified Bingpeng Power Mouthwash on immune function in patients with head and neck cancer radiotherapy [J]. 中国医药导报, 2020, 17(26): 91-94.

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http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2020/V17/I26/91

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