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| Relationship between serum β-amyloid protein and cognitive dysfunction in patients with liver failure |
| ZHU Zhou CHEN Guanfeng LIU Yongping SHAO Sen▲ |
| Department of Neurology, Hangzhou Xixi Hospital, Zhejiang Province, Hangzhou 310023, China |
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Abstract Objective To study the relationship between serum β-amyloid protein (Aβ) and cognitive dysfunction in patients with liver failure and provide guidance for clinical research. Methods From April 2019 to April 2020, 104 patients with liver failure admitted to the Zhejiang Hangzhou Xixi Hospital (hereinafter referred to as “our hospital”) were selected for study. The cognitive function was assessed by the Montreal cognitive assessment scale (MoCA) and the patients were divided into the cognitive-normal group (n = 56, MoCA score ≥ 26 points) and the cognitive-impaired group (n = 48, MoCA score <26 points), in addition, 52 healthy controls in the Medical Center in our hospital were selected as the control group. Serum Aβ was detected by enzyme-linked immunosorbent assay to determine the relationship between serum Aβ and cognitive dysfunction in patients with liver failure. Results MoCA score, levels of Aβ 1-40 and Aβ 1-42 were compared among the three groups, and the differences were statistically significant (P ＜ 0.05). MoCA score and Aβ 1-42 levels in the cognitive impairment group were significantly lower than those in the cognitive-impaired and control groups, and Aβ 1-40 levels in the cognitive-impaired group were significantly higher than those in the normal and control groups, with statistically significant differences (P ＜ 0.05). Logistic regression analysis showed that, age > 55, high Aβ 1-40 level, and low Aβ 1-42 level were independent risk factors for cognitive dysfunction in patients (P ＜ 0.05). Correlation analysis showed that cognitive dysfunction in patients with liver failure was positively correlated with Aβ 1-42 level (r = 0.685, P = 0.000) and negatively correlated with Aβ 1-40 level (r = -0.714, P = 0.000). Conclusion Serum Aβ 1-42 levels are significantly decreased in patients with cognitive dysfunction of liver failure, which is positively correlated with MoCA score; serum Aβ 1-40 levels are significantly increased, which is negatively correlated with MoCA score. Both of them are risk factors for the occurrence of cognitive dysfunction, and their detection combined with MoCA assessment could provide certain reference for clinical diagnosis.
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