外周血淋巴细胞亚群比例紊乱与帕金森病的相关性研究

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Abstract Objective To explore the correlation between neural immune mechanisms and the occurrence of Parkinson′s disease (PD) by detecting the percentage differences of lymphocyte subtypes in peripheral blood of patients with PD. Methods Fluorescence staining method was used to determine the periphery of primary PD patients (case group, 83 cases) admitted to the First Affiliated Hospital of Xinjiang Medical University (“our hospital” for short) from June 2014 to July 2017 and healthy physical examination patients (control group, 100 cases) in our hospital during the same period, while the differences in the percentage of CD3+, CD4+, CD8+, CD19+, CD56+, Fas and Tregs cells in the blood were measured, and the correlation between whether the patients in the case group took the drug Compound Levodopa, Hoehn-Yahr (HY) grade difference and the changes of lymphocyte subsets were analyzed. Results CD3+, CD4+, and CD8+ in the case group were lower than those in the control group, while the positive subsets of CD56+ cells, Fas and Tregs were higher than those in the control group, and the differences were highly statistically significant (P ＜ 0.01). Fas and Tregs cell subsets in the medication group were lower than those in the non-administration group, and the differences were statistically significant (P ＜ 0.05). Correlation analysis showed that the number of Fas and Tregs positive cells were positively correlated with HY grade (r = 0.620, 0.761, P ＜ 0.05). Conclusion Peripheral blood lymphocyte subsets of PD patients have a disorder in the proportions. The the proportion of Fas and Tregs cells are related to the severity of the disease in PD patients. For PD patients who are not treated with oral Compound Levodopa, the proportion will further increase.

Key words： Parkinson′s disease Death receptor T lymphocyte B lymphocyte Tregs cell

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	WANG Yuling1
	2 YAO Ya′ni2 GAO Hua3 XIA Huan4 YANG Xinling1▲

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WANG Yuling1,2 YAO Ya′ni2 GAO Hua3 XIA Huan4 YANG Xinling1▲. Correlation between the disorder of peripheral blood lymphocyte subsets ratio and Parkinson′s disease[J]. 中国医药导报, 2020, 17(26): 49-52.

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http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2020/V17/I26/49

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