血清SHBG表达及对维吾尔族妊娠期糖尿病诊断价值

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Abstract Objective To investigate serum sex hormone binding globulin (SHBG) expression in gestational diabetes mellitus (GDM) of Uygur women in Xinjiang and its diagnostic value for GDM. Methods From August 2018 to August 2019, 100 cases with Uygur GDM patients in the Second Affiliated Hospital of Xinjiang Medical University were selected as the observation group, 100 Uygur pregnant women in the same period of health examination as the control group. The serum SHBG, fasting blood glucose, fasting insulin, glycosylated hemoglobin (HbA1c) and fasting C peptide level were compared between the two groups of pregnant women in early, middle and late pregnancy. The HOMA-IR was calculated, and the correlation between SHBG level in early pregnancy and other indicators were recorded. The receiver operating characteristic (ROC) was used to analyze the diagnostic value of SHBG level in early pregnancy for GDM. Results The serum SHBG levels in the observation group were lower than those in the control group in early middle and late pregnancy, and the differences were statistically significant (P < 0.05). HbA1c, fasting C peptide level, fasting blood glucose, fasting insulin and HOMA-IR in the observation group were higher than those in the control group in early middle and late pregnancy, and the differences were statistically significant (all P < 0.05). Serum SHBG level of early pregnancy was negatively correlated with HOMA-IR values (r = -0.869, P < 0.01). The area under the curve of SHBG level in the early pregnancy for diagnosis of GDM was 0.877. Conclusion In different pregnancy stages, serum SHBG level of Uygur GDM pregnant women in Xinjiang is lower and negatively correlated with IR degree. Serum SHBG level in early pregnancy can be an important biochemical indicator for early diagnosis of GDM.

Key words： Uygur Gestational diabetes mellitus Sex hormone binding globulin Insulin resistance

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	SHEN Juanjuan CAI Juejin HA Liya

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SHEN Juanjuan CAI Juejin HA Liya. Serum SHBG expression and diagnostic value for Uygur gestational diabetes mellitus[J]. 中国医药导报, 2020, 17(20): 111-114.

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http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2020/V17/I20/111

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