射频消融术联合肝动脉化疗栓塞治疗原发性肝癌伴门静脉癌栓的临床效果

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Abstract Objective To investigate the clinical effect of radio frequency ablation (RFA) combined with trans catheter arterial chemoembolization (TACE) in the treatment of primary liver cancer (PHC) with portal vein tumor thrombus (PVTT). Methods A total of 80 PHC patients with PVTT in Jiangmen Central Hospital, Guangdong Province were retrospectively selected from January 2013 to May 2016. According to different treatment methods, they were divided into the study group and the control group, with 40 patients in each group. The control group was treated with TACE and the study group was treated combined with RFA on the basis of the control group. The curative effect, liver function and adverse reactions of the two groups were compared, and the survival of the two groups during the follow-up period was recorded. Results The total clinical response rate of the study group was higher than that of the control group, and the difference was statistically significant (P ＜ 0.05). After treatment, glutamate aminotransferase (ALT), aspartate aminotransferase (AST), total bilirubin (TBil), alpha fetoprotein (AFP) in the two groups were all decreased compared with those before treatment, while the study group was lower than the control group, with statistically significant differences (all P ＜ 0.05). There was no significant difference in the incidence of adverse reactions between the two groups during treatment (P ＞ 0.05). K-M survival curve analysis found that the survival rate of the study group was significantly higher than that of the control group, with statistically significant difference (P ＜ 0.05). Conclusion PHC patients with PVTT after RFA combined with TACE treatment, the curative effect is accurate, safety is good, the survival rate and survival time of the patients can be improved, and the liver function of the patients can be improved.

Key words： Radio frequency ablation Trans catheter arterial chemoembolization Primary liver cancer Portal vein tumor thrombus

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	RUAN Jianqiu1 CHEN Xin1 ZHANG Honghuan1 YANG Jinzhao2 LI Ronggang3

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RUAN Jianqiu1 CHEN Xin1 ZHANG Honghuan1 YANG Jinzhao2 LI Ronggang3. Clinical effect of radio frequency ablation combined with trans catheter arterial chemoembolization in the treatment of primary liver cancer with portal vein tumor thrombus[J]. 中国医药导报, 2020, 17(20): 25-28,33.

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http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2020/V17/I20/25

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