健脾消胀方脐部敷贴治疗脓毒症胃肠功能障碍的临床效果

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Abstract Objective To explore clinical effect of Jianpi Xiaozhang Decoction umbilical paste in the treatment of sepsis patients with gastrointestinal dysfunction. Methods Eighty sepsis patients with gastrointestinal dysfunction hospitalized in Emergency Intensive Care Unit of the Seventh People′s Hospital Affiliated to Shanghai University of Traditional Chinese Medicine from July 2017 to February 2019 were selected and randomly divided into treatment group (40 cases) and control group (40 cases) by random number table method. Two groups were given basic treatment. In treatment group, shenque point was pasted with Jianpi Xiaozhang Decoction on the basis of basic treatment, the course was 7 days. The sequential organ function (SOFA) score, gastrointestinal dysfunction score, gastrointestinal dysfunction index level and comprehensive efficacy between two groups were compared. Results The score of SOFA in control group after treatment was higher than that before treatment (P ＜ 0.05). After treatment, the scores of SOFA and intraperitoneal pressure in treatment group were lower than those before treatment and in control group, and the peritoneum in treatment group was shorter than that before treatment and in control group (P ＜ 0.05). The scores of gastrointestinal dysfunction and traditional Chinese medicine syndrome in control group after treatment were lower than those before treatment (P ＜ 0.05). After treatment, the number of bowel sounds in treatment group was more than that before treatment and in control group, and the scores of gastrointestinal dysfunction and traditional Chinese medicine syndrome were lower than those before treatment and in control group (P ＜ 0.05). The level of serum intestinal fatty acid binding protein (IFABP) in control group after treatment was lower than that before treatment (P ＜ 0.05). The levels of IFABP and D-lactate in treatment group were lower than those before treatment and in control group (P ＜ 0.05). The total effective rate of Chinese medicine syndrome effect and comprehensive effect of treatment group was higher than control group, the difference was statistically significant (P ＜ 0.05). The incidence of multiple organ dysfunction syndrome of treatment group was lower than control group, the difference was statistically significant (P ＜ 0.05). Conclusion Jianpi Xiaozhang Decoction umbilical paste can improve clinical symptoms such as abdominal distention, abdominal pain, fatigue and defecation, enhance gastrointestinal motility, improve gastrointestinal barrier function and the state of ischemia and anoxia.

Key words： Jianpi Xiaozhang Decoction Umbilical paste Intestinal fatty acid binding protein D-lactate Sepsis Gastrointestinal dysfunction

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	ZHANG Jidan ZHANG Lifen ZHU Yuanqing XU Zhibing

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ZHANG Jidan ZHANG Lifen ZHU Yuanqing XU Zhibing. Clinical effect of Jianpi Xiaozhang Decoction umbilical paste in the treatment of sepsis with gastrointestinal dysfunction[J]. 中国医药导报, 2020, 17(19): 123-127.

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http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2020/V17/I19/123

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