槐耳颗粒联合紫杉醇和奥沙利铂治疗晚期胃癌的临床研究

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Abstract Objective To explore the clinical effect of Huaier Granule combined with Taxol and Oxaliplatin in the treatment of advanced gastric cancer. Methods A total of 100 patients with advanced gastric cancer who were treated in Chenzhou NO.1 People′s Hospital from January 2017 to January 2019 were selected as the research object, while they were divided into observation group (50 cases) and control group (50 cases) by random number table method. The control group was treated with Taxol and Oxaliplatin, and the observation group was treated with Huaier Granules on the basis of the control group. The clinical efficacy, serum carcinoembryonic antigen (CEA), sugar chain antigen 724 (CA724), sugar chain antigen 199 (CA199), T lymphocyte subsets, quality of life and adverse reactions were compared between the two groups. Results The total effective rate of the observation group was higher than that of the control group, and the difference was statistically significant (P ＜ 0.05). After treatment, the levels of CEA, CA724, and CA199 in the two groups were significantly lower than those before treatment, while the observation group were lower than those in the control group, and the differences were statistically significant (P ＜ 0.05). The levels of CD3+, CD4+, CD4+/CD8+ in the two groups were significantly higher than those before treatment, while the observation group were higher than those in the control group; the CD8+ levels of the two groups were significantly lower than those before treatment, while the observation group was lower than the control group, and the differences were statistically significant (P ＜ 0.05). The quality of life of the two groups were significantly higher than those before treatment, while the observation group was higher than the control group, and the differences were statistically significant (P ＜ 0.05). The total incidence of adverse reactions between the two groups was not statistically significant (P ＞ 0.05). Conclusion The use of Huaier Granules combined with Taxol and Oxaliplatin in patients with advanced gastric cancer has a significant effect, which can effectively improve the serum tumor marker levels and quality of life of patients.

Key words： Huaier Granules Taxol Oxaliplatin Advanced gastric cancer

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	XU Ming1 TANG Shu2 LIU Qi3

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XU Ming1 TANG Shu2 LIU Qi3. Clinical study of Huaier Granules combined with Taxol and Oxaliplatin in the treatment of advanced gastric cancer[J]. 中国医药导报, 2020, 17(19): 97-100.

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http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2020/V17/I19/97

[1] 孙健，李丽，钱婷，等.多西紫杉醇联合替吉奥及奥沙利铂方案一线治疗晚期胃癌的临床研究[J].实用癌症杂志，2019，34（2）：211-214.
[2] 王娜，郭军，孙雅薇，等.雷替曲塞注射剂联合奥沙利铂注射剂治疗晚期胃癌的临床研究[J].中国临床药理学杂志，2017，33（19）：1886-1888.
[3] 许丽芳，隋昕珂，周学慧，等.贝伐珠单抗联合奥沙利铂+氟尿嘧啶方案对晚期胃癌患者疾病控制及对CEA、CA199、CA72-4、TAM水平表达的影响[J].疑难病杂志，2018，17（12）：1357-1361.
[4] 常娜，戴小军，陆清昀，等.126例晚期胃癌患者中医证素特点研究[J].国际中医中药杂志，2017，39（2）：110-113.
[5] 冯惠岗，唐映，何超雄，等.经导管肝动脉化疗栓塞术联合放射性125I粒子及槐耳颗粒治疗中晚期肝癌的疗效分析[J].中华生物医学工程杂志，2017，23（1）：72-75.
[6] 中华人民共和国卫生部医政司.胃癌诊疗规范（2011年版）[J].中国医学前沿杂志：电子版，2012，4（5）：62-71.
[7] 王玉凤，商敏，关淑芬，等.老年肺癌患者服用吉非替尼期间SF-36生活质量问卷评分的意义[J].中国老年学杂志，2015，35（9）：2516-2518.
[8] 王永领，陈青梅，王文珣，等.多柔比星脂质体、奥沙利铂联合替吉奥治疗晚期胃癌临床观察[J].现代诊断与治疗，2019，30（9）：1445-1446.
[9] 甄振华，申传厚，杜文凯.阿帕替尼联合槐耳颗粒治疗晚期原发性肝癌的临床疗效[J].现代肿瘤医学，2019，27（17）：3086-3089.
[10] Probst A，Schaller T，Sommer F，et al. Immunoglobulin G4（IgG4）-related disease of the stomach- a challenging differential diagnosis in suspected gastric cancer [J]. Z Gastroenterol，2019，57（11）：1298-1303.
[11] 陈洋，符秋红.紫杉醇联合奥沙利铂治疗老年晚期胃癌的疗效分析[J].实用癌症杂志，2018，33（6）：971-973.
[12] Oi H，Yamamoto S，Kono Y，et al. A case of Lymphoepithelioma-like carcinoma（LELC）developed in the rectum [J]. Rep Pract Oncol Radiother，2019，24（6）：624-628.
[13] 余姣，吴驭，蔡懿.槐耳颗粒联合替吉奥治疗老年晚期胃癌的临床疗效观察[J].实用癌症杂志，2019，34（9）：1505-1507，1511.
[14] 张庆辉，梁艳华.槐耳颗粒联合索拉非尼对原发性肝癌术后复发患者的临床疗效研究[J].实用癌症杂志，2019， 34（9）：1560-1562.
[15] Wu X，Huang S. HER2-specific chimeric antigen receptor-engineered natural killer cells combined with apatinib for the treatment of gastric cancer [J]. Bull Cancer，2019，106（11）：946-958.
[16] 冯晓玲，李新岩.血清lncRNA PTENP1联合CA724、CA19-9、癌胚抗原检测在胃癌诊断及预后中的价值[J].国际消化病杂志，2019，39（5）：335-340.
[17] 刘志华.肿瘤标志物检测在肾脏疾病临床诊疗中的应用价值分析[J].中国医药科学，2019，9（9）：118-120.
[18] 许卫娜，王婷.患者血清CEA、CA724、CA199水平对胰腺癌的评估价值[J].实用癌症杂志，2019，34（5）：747-749.
[19] 詹鹏，韩涛，杨晓丹，等.雷替曲塞联合槐耳颗粒二线治疗晚期胃癌临床观察[J].临床军医杂志，2017，45（1）：24-26.
[20] 谈震东，杨文杰.槐耳颗粒在三阴性乳腺癌根治术后化疗中辅助治疗的临床效果[J].实用癌症杂志，2017，32（11）：1893-1895.
[21] 何超雄，冯惠岗，翁裕，等.TACE联合放射性125I粒子及槐耳颗粒治疗中晚期肝癌的临床研究[J].中国医学创新，2018，15（6）：13-16.
[22] 鲁明骞，冯雪松，孔庆志，等.槐耳颗粒对乳腺癌术后化疗患者免疫功能及生活质量的影响[J].东南大学学报：医学版，2017，36（4）：567-571.
[23] Takahashi Y，Fukuyama T，Futawatari N，et al. Expression of Kita-Kyushu Lung Cancer Antigen-1 as Detected by a Novel Monoclonal Antibody in Gastric Cancer [J]. Anticancer Res，2019，39（11）：6259-6263.