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| Relationship between the expression of IgE, IgG1 and T cell activation in anaphylactic shock caused by cystic echinococcosis |
| LI Jie DAI Qing Yali·Yasen NIU Yue MA Yan |
| Department of Anesthesiology, the First Affiliated Hospital of Xinjiang Medical University, Xinjiang Uygur Autonomous Region, Urumqi 830054, China |
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Abstract Objective To explore the relationship between specific allergens and T cell activation during anaphylactic shock caused by cystic echinococcosis, and to provide new ideas for clinical treatment. Methods Serum was collected from 30 patients (research group) who were underwent cystic hydatid cystectomy in the First Affiliated Hospital of Xinjiang Medical University from January 2015 to December 2017. The patients with anaphylactic shock during the operation were taken as the anaphylactic shock group (10 cases), while patients without anaphylactic shock were taken as the non-anaphylactic shock group (20 cases), and the blood samples of healthy examinees from the same period were selected as the control group (30 people). The levels of serum immunoglobulin (Ig) E and IgG1 in each group were analyzed, while the expression levels of interleukin (IL)-10, IL-4, IL-2 and γ interferon (IFN-γ) in the serum of each group were detected, and correlation analysis was performed. Results The expression levels of IgE and IgG1 during the operation in the anaphylactic shock group were higher than those in the non-anaphylactic shock group, and the differences were statistically significant (P ＜ 0.05). There were no statistically significant differences in serum IgE and IgG1 expression levels among the groups after 1 week of operation (P ＞ 0.05). The expression levels of serum IL-4 and IL-10 before the operation in the study group were higher than those in the control group, and the differences were statistically significant (P ＜ 0.05). The serum IL-4 and IL-10 during the operation in the anaphylactic shock group were lower than those in the non-anaphylactic shock group, while the IFN-γ and IL-2 were higher than those in the non-anaphylactic shock group, and the differences were statistically significant (P ＜ 0.05). The serum IL-4 and IL-10 expression levels of the anaphylactic shock group were higher than those of the non-anaphylactic shock group and the control group after 1 week of operation, and the differences were statistically significant (P ＜ 0.05). IgE was positively correlated with IL-2 and IFN-γ (r = 0.96, 0.68, P ＜ 0.05), while IgG1 was positively correlated with IL-2 and IFN-γ (r = 0.60, 0.79, P ＜ 0.05). Conclusion As long as anaphylactic shock occurs, Th1 and Th2 type cells are imbalanced. Th1 type plays a leading role in anaphylactic shock, and its activation is related to IgE and IgG1.
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