宫颈高危型人乳头瘤病毒感染与阴道微生态及局部细胞免疫的关系

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Abstract Objective To investigate the relationship between high risk human papillomavirus (HPV) infection and vaginal microecology and local cellular immunity. Methods From February 2017 to June 2019, 218 female patients with cervicitis who came to Kunming Maternal and Child Health Hospital were selected as the study subjects. All patients were tested for high risk HPV examination, according to the results, they were divided into observation group (n = 80, high risk HPV positive), control group (n = 138, high risk HPV negative). The vaginal microecology disorders and cervical local cell immunity were compared between two groups. Pearson correlation analysis was used to analyze the relationship between cervical high risk HPV infection and vaginal microecology and cervical local cellular immunity. Results Eighty cases were found to be high risk HPV infection, the positive rate was 36.70% (80/218), among which HPV16 was the highest (52.50%), followed by HPV52 (22.50%). The vaginal microecology disorder, mycoplasma, ureaplasma urealyticum, chlamydia, lactobacillus abnormal rate and bacterial vaginitis rate in observation group were higher than those in control group (P < 0.05). CD4+, CD4+/CD8+ in observation group were lower than those in control group (P < 0.05). High risk HPV infection was negatively correlated with CD4+, CD4+/CD8+ (r = -0.453,-0.421, P < 0.05), while positively correlated with bacterial vaginitis, chlamydia, lactobacillus and ureaplasma urealyticum (r = 0.432,0.525, 0.504,0.472, P < 0.05). Conclusion Cervical high risk HPV infection is closely related to vaginal microecology and cervical local cellular immunity, which can aggravate the disorder of vaginal microecology and reduce the local cellular immune function of patients.

Key words： High risk human papillomavirus Vaginal microecology Cervix Local cellular immunity Relationship

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	TANG Qinghua1
	2 LI Yanping3

Cite this article:

TANG Qinghua1,2 LI Yanping3. Relationship between cervical high risk human papillomavirus infection and vaginal microecology and local cellular immunity[J]. 中国医药导报, 2020, 17(18): 107-110.

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http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2020/V17/I18/107

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