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| Relationship between resistance rate of Klebsiella pneumoniae and the intensity of commonly used antibiotics |
| LIU Dongling SHI Lei |
| Department of Pharmacy, Liaocheng People′s Hospital, Shandong Province, Liaocheng 252000, China |
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Abstract Objective To investigate the relationship between the resistance rate of Klebsiella pneumoniae and the intensity of commonly used antibiotics. Methods The strains isolated from 120 patients in Liaocheng People′s Hospital from February 2018 to February 2019 were isolated and cultured. Automatic microbial identification system and drug sensitivity test were used to isolate, culture and identify. The drug resistance rate of Klebsiella pneumoniae and the use intensity of antibiotics were calculated. Results The resistance of Klebsiella pneumoniae to Ceftriaxin, Ceftriaxone, Gentamycin, Penicillin and Ampicillin Sulbactam was high. The use intensity of third generation cephalosporins, compound preparations containing β lactamase inhibitors, quinolones and penicillins were high, and the use intensity of the first, second generation cephalosporins and aminoglycosides were lower. The drug resistance of Klebsiella pneumoniae was positively correlated with quinolones (r = 0.674, P = 0.021), penicillins (r = 0.682, P = 0.019), third-generation cephalosporins (r = 0.525, P = 0.033), compound preparations containing β lactamase inhibitors (r = 0.558, P = 0.029), and negatively correlated with fourth generation cephalosporins （r = -0.524, P = 0.036). There was no correlation with the first generation cephalosporins (r = 0.146, P = 0.101), the second generation cephalosporins (r = 0.104, P = 0.142), carbapenem (r = 0.123, P = 0.124) and aminoglycosides (r = 0.173, P = 0.092). Conclusion There is a certain correlation between Klebsiella pneumoniae and the intensity of commonly used antibiotics. Antibiotics should be selected reasonably in clinical use to prevent the abuse of antibiotics.
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