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| Investigation study on the epidemiological of hypothyroidism in pregnancy |
| CAI Le′nan1,2 WANG Pan3 XU Yueqing1 |
1.Department of Nursing, College of Nursing, Hebei University, Hebei Province, Baoding 071000, China;
2.Department of Pediatrics, Dingzhou People′s Hospital, Hebei Province, Dingzhou 073000, China;
3.Department of Oncology, Dingzhou People′s Hospital, Hebei Province, Dingzhou 073000, China |
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Abstract Objective To explore the epidemiological characteristics of hypothyroidism in pregnancy, and to analyze its influencing factors. Methods The clinical data of 1000 pregnant women who were admitted to Dingzhou People′s Hospital in Hebei Province from December 2017 to December 2018 were retrospectively selected. The prevalence of hypothyroidism in pregnancy was screened. Univariate and multivariate logistic regression were used to analyze the influencing factors of hypothyroidism in pregnancy. Results Of the 1000 pregnant women included in this study, 392 pregnant women had hypothyroidism, the prevalence rate was 39.20%. Among them, 127 pregnant women had clinical hypothyroidism, accounting for 32.40%, 265 pregnant women had subclinical hypothyroidism, accounting for 67.60%. Univariate analysis showed that the incidence of hypothyroidism in pregnancy with age≥30 years, number of pregnancies≥2 times, education below junior college, parity≥3 times, history of spontaneous abortion, diabetes mellitus, hypertensive disorder of pregnancy, low iodine intake, thyroid peroxidase antibody positive, birth interval≥48 months were higher (P < 0.05). Multivariate logistic regression analysis showed that age≥30 years, number of pregnancies≥2 times, education below junior college, parity≥3 times, history of spontaneous abortion, diabetes mellitus, hypertensive disorder of pregnancy, low iodine intake, birth interval≥48 months were independent risk factors for hypothyroidism in pregnancy (P < 0.05). Conclusion Hypothyroidism has a high prevalence rate in pregnant women, which should be detected early and given high attention clinically. They can make scientific preventive measures to reduce the occurrence of disease according to its influencing factors
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[1] 柯文才，顾芸霞.不同妊娠期孕妇甲状腺激素水平的研究分析[J].检验医学，2015，30（3）：224-226.
[2] 蒋晶，高丽娜.妊娠期甲状腺功能减退对妊娠结局的影响[J].中国基层医药，2019，26（7）：814-817.
[3] 罗希，赵锦秀，吴君，等.原发性甲状腺功能减退症孕妇甲状腺素替代治疗对甲状腺功能及母婴结局的影响[J].标记免疫分析与临床，2019，26（7）：1155-1158.
[4] 曹泽毅.中华妇产科学[M].北京：人民卫生出版社，2010：2600-2650.
[5] 李嫔.孕期甲状腺疾病对胎儿发育及新生儿健康的影响[J].中华实用儿科临床杂志，2019，34（8）：574-577.
[6] 张莉，孙伟杰，高莹，等.早孕期甲状腺疾病筛查模式探讨[J].中华围产医学杂志，2016，19（3）：182-187.
[7] 王国成，麻伟博，孙红敏，等.妊娠期甲状腺疾病及其相关诊断指标的参考值范围研究现状[J].中华妇幼临床医学杂志：电子版，2017，13（5）：503-510.
[8] 王丽霞，周群艳.妊娠期甲状腺功能减退对妊娠结局和母儿的影响[J].中国妇幼健康研究，2018，29（9）：1094-1097.
[9] 程小侠，史征，王玉珠，等.妊娠期甲状腺功能减退与妊娠不良结局的相关性分析[J].中国临床医生杂志，2015， 43（8）：68-70.
[10] 李进，张丽梅，于宁，等.妊娠期亚临床甲减对妊娠结局及围产儿的影响及甲状腺激素替代治疗效果观察[J].中国计划生育学杂志，2019，27（1）：91-94.
[11] 吕冬青.妊娠期甲状腺功能减退症患病情况及影响因素分析[D].太原：山西医科大学，2019.
[12] 吴洪秋，黄坚尧，黄武炎，等.孕早中期孕妇轻度甲状腺功能减退症的影响因素及与不良妊娠结果的关系研究[J].国际检验医学杂志，2017，38（14）：1977-1979.
[13] 王文美，余晓敏.孕早、中期甲状腺功能减退与年龄因素的相关性分析[J].中国妇幼健康研究，2015，26（3）：499-500，516.
[14] 李春莉，杨梅，宋涛，等.妊娠期妇女甲状腺激素水平及相关影响因素分析[J].中国妇幼保健，2019，34（11）：2498-2501.
[15] 景蓉，李秀琴.妊娠期甲状腺功能减退与妊娠期糖尿病对妊娠结局的影响及相关性分析[J].解放军医药杂志，2017，29（8）：66-71.
[16] 王莉，张博，张颖，等.渭南地区妊娠期甲状腺功能减退的临床特点分析[J].中国生育健康杂志，2016，27（3）：262-264.
[17] 曹会荣，梁媛哲，秦淼，等.妊娠期甲状腺功能减退和妊娠期糖尿病发生风险的相关性[J].河北医药，2017，39（24）：3787-3788，3791.
[18] 朱文元，向菲，杨洪芬，等.贵阳市观山湖区妊娠期妇女碘营养状况与甲状腺激素水平的相关性研究[J].中华地方病学杂志，2018，37（1）：54-58.
[19] Conde-Agudelo A，Rosas-Bermudez A，Casta?觡o F，et al. Effects of birth spacing on maternal，perinatal，infant，and child health：a systematic review of causal mechanisms [J]. Stud Fam Plann，2012，43（2）：93-114.
[20] 吴智梅，罗娟.妊娠期甲状腺功能减退症患者TSH、FT4、TPOAb、TGAb与妊娠结局的相关性[J].中国医师杂志，2017，19（11）：1738-1741. |
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