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| Analysis on the factors affecting the pregnancy rate of ovulatory cycle artificial insemination |
| ZHOU Zhi1 MA Ning1 TU Zhihua1 LI Haibo2 |
1.Hainan Maternal and Child Health Hospital, Hainan Province, Haikou 570206, China;
2.Suzhou Hospital Affiliated to Nanjing Medical University, Jiangsu Province, Suzhou 215000, China |
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Abstract Objective To analysis the influencing factors of success rate of intrauterine artificial insemination (IUI) in ovulation-promoting cycle. Methods A retrospective analysis of 500 cycles of ovulation-promoting IUI and clinical data of patients at Hainan Maternal and Child Health Hospital and Suzhou Hospital Affiliated to Nanjing Medical University from July 2015 to June 2017, the female age, infertility years, IUI cycle, the number of IUI times per cycle, the number of ovulation inducing scheme, the number of dominant follicles, and whether or not human chorionic gonadotropin (HCG) inducing ovulation and its correlation with the clinical pregnancy rate were explored. The independent factors affecting clinical pregnancy rate of IUI were analyzed by logistic regression analysis. Results A total of 117 patients were successfully pregnant after IUI, with a pregnancy rate of 23.40%. The univariate analysis showed that the effect of female age and the number of dominant follicles on the clinical pregnancy rate of IUI was significant (P < 0.05), there were no statistically significant differences in the effects of infertility years, IUI cycles, the number of IUI in each cycle, the ovulation-promoting regimen, and whether or not HCG induced ovulation on the clinical pregnancy rate of IUI (P > 0.05). logistic regression analysis showed that the age of women (OR = 2.128, 95%CI: 1.018-4.162, P < 0.05) and the number of dominant follicles (OR = 3.617, 95%CI: 0.855-7.282, P < 0.05) were independent influencing factors of the clinical pregnancy rate of IUI in the ovulation-promoting cycle. Conclusion Female age and the number of dominant follicles are key factors in the clinical pregnancy rate of the IUI during the ovulation-promoting cycle, age is a risk factor, and the number of dominant follicles is a protective factor.
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