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| Effect of Buqi Liangxue Decoction combined with Oxytocin in the treatment of postpartum hemorrhage and its influence on inflammatory factors and oxidative stress |
| ZHOU Ling SUN Hong LING Li LU Jin ZHANG Hong |
| Department of Obstetrics and Gynecology, the Second Affiliated Hospital of Suzhou University, Jiangsu Province, Suzhou 215000, China |
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Abstract Objective To explore the effect of Buqi Liangxue Decoction combined with Oxytocin in the treatment of postpartum hemorrhage and its influence on inflammatory factors and oxidative stress. Methods One hundred and sixty-eight patients with postpartum hemorrhage admitted to the Second Affiliated Hospital of Suzhou University from August 2017 to August 2019 were selected retrospectively. According to the different treatment methods, they were divided into control group (n = 83, Oxytocin treatment) and study group (n = 85, Buqi Liangxue Decoction combined with Oxytocin treatment). Both groups were treated for 7 days. Clinical effect, bleeding, uterine regurgitation on the 1st, 3th and 7th day of postpartum, serum levels of C-reactive protein (CRP), tumor necrosis factor-α (TNF-α), interleukin-8 (IL-8), lipid peroxide (LPO), glutathion peroxidase (GSH-Px), superoxide dismutase (SOD) before and after treatment and adverse reactions were compared between two groups. Results Total clinical effective rate of study group was higher than that of control group (P < 0.05). The bleeding time of study group was shorter than that of control group, the amount of blood loss and the number of bleeding cases in the later period were less than control group (P < 0.05). There were significant differences in the height of uterine fundus among groups, time points and interaction (P < 0.05). Intra group comparison: with the prolongation of treatment time, the height of uterine fundus in both groups decreased gradually (P < 0.05). Comparison between groups: there was no significant difference between two groups in the height of the uterine fundus on the first day after delivery (P > 0.05); on the third and seventh days after delivery, the height of the uterine fundus in study group were lower than those in control group (P < 0.05). After treatment, TNF-α, CRP and IL-8 levels in two groups were lower than those before treatment, and study group was lower than control group (P < 0.05). LPO level of two groups after treatment was lower than that before treatment, and study group was lower than control group (P < 0.05). The levels of SOD and GSH-Px in two groups after treatment were higher than those before treatment, and those in study group were higher than those in control group (P < 0.05). There was no significant difference in the incidence of adverse reactions between two groups (P > 0.05). Conclusion The effect of Buqi Liangxue Decoction combined with Oxytocin in the treatment of postpartum hemorrhage is definite. The condition of uterine regurgitation is good, it can decrease the level of serum inflammatory factors, reduce the oxidative stress response of patients, which can provide reference for clinical treatment.
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