布洛芬联合盐酸米诺环素对重度慢性牙周炎基础治疗效果及炎性因子的影响

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Abstract Objective To investigate the effect of Ibuprofen combined with Minocycline Hydrochlorideon basic treatment and inflammatory factors of severe chronic periodontitis. Methods A total of 78 patients with severe chronic periodontitis diagnosed and treated in Jinhua Central Hospital of Zhejiang Province from March 2017 to March 2019 were selected. They were divided into study group (39 cases) and control group (39 cases) according to the random number table method. The control group was given periodontal mechanical therapy. The study group was treated with Ibuprofen on the basis of the control group. After 4 weeks of treatment, the clinical effect, inflammatory factor level, immune function, periodontal index and adverse reactions were compared between the two groups. Results The total clinical effective rate of the study group was higher than that of the control group after 4 weeks of treatment (P ＜ 0.05). Compared with before treatment, interleukin (IL)-6, IL-8, tumour necrosis factor-α and hypersensitive C-reactive protein in both groups were decreased after 4 weeks of treatment, and the study group were lower than those of the control group (P ＜ 0.05). Compared with before treatment, CD4+ and CD4+/CD8+ in both groups were increased after 4 weeks of treatment, while CD8+ was decreased (P ＜ 0.05). The CD4+ and CD4+/CD8+ in the study group were higher than those in the control group, while CD8+ was lower than that in the control group (P ＜ 0.05). Compared with before treatment, the gingival sulcus bleeding index, plaque index and periodontal pocket depth of the two groups were all reduced after 4 weeks of treatment, and the study group were lower than those of the control group (P ＜ 0.05). There was no statistically significant difference in the incidence of adverse reactions between the two groups (P ＞ 0.05). Conclusion Ibuprofen combined with Minocycline Hydrochloride in the treatment of severe chronic periodontitis can effectively improve the immune function and alleviate inflammatory reaction, and the drug is safe and effective.

Key words： Ibuprofen Minocycline Hydrochloride Severe chronic periodontitis Inflammatory factors Efficacy

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	PU Lili1 CHEN Danhua2 XUE Jing1

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PU Lili1 CHEN Danhua2 XUE Jing1. Effect of Ibuprofen combined with Minocycline Hydrochloride on basic treatment and inflammatory factors of severe chronic periodontitis[J]. 中国医药导报, 2020, 17(12): 124-127.

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http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2020/V17/I12/124

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