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| Research progress on metabonomics biomarkers of major depressive disorder |
| QI Yonghua SUN Hui WANG Xijun |
| Research Center of Traditional Chinese Medicine Prescription Metabolomics, National Administration of Traditional Chinese Medicine, Heilongjiang University of Chinese Medicine, Heilongjiang Province, Harbin 150040, China |
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Abstract Major depressive disorder (MDD) is a major mental disorder worldwide, it causes enormous economic and emotional stress on society. The discovery of biomarkers can not only improve the diagnosis of depression and accelerate the development of new drugs, but also be used to predict the likelihood of depression and advance the process of personalized treatment of MDD. In recent years, the rapid development of metabolomics and its extensive application in disease diagnosis have provided the possibility for further screening of MDD related biomarkers. This paper will summarize and discuss the research progress of metabonomics biomarkers in the MDD based on the metabolomics of blood, urine and cerebrospinal fluid, with the purpose of enabling researchers to make new discoveries on the basis of existing studies, and expect the biomarker of MDD to play an important role in clinical practice as soon as possible to improve the quality of life of MDD patients.
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