外周血内sST2水平评价急性心力衰竭患者病情严重程度及预后质量的临床价值分析

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Abstract Objective To discuss the clinical value of peripheral blood sST2 on risk stratification and prognosis in patients with acute heart failure (AHF). Methods From June 2014 to December 2015, in Xuzhou Central Hospital, 162 AHF patients were selected, 58 healthy persons were chosen as control group. All patients were followed-up 1 year after AHF attack. The incidence of end point was recorded. The sST2 levels were determined by ELISA and the levelsof NT-proBNP and TNI were detected by automatic biochemical analyzer. The value of them on prognosis were analyzed by ROC curve. Results The levels of sST2, NT-proBNP and TNI in AHF patients were significantly higher than healthy people, the differences were statistically significant (P < 0.05). The levels of sST2, NT-proBNP and TNI in mild AHF patients were significantly higher than severe AHF patients, the differences were statistically significant (P < 0.05); 63 patients occurred recurrence of heart failure or cardiac death, and the incidence of the end of observation was 38.89%, the sST2 level in AHF patients with the end of observation was significantly higher than AHF patients without the end of observation, the differences were statistically significant (P < 0.05). The results of Logistic multifactor regression analysis showed thatthe levels of sST2, NT-proBNP and clinical heart function grade had independent predicting value of AHF (OR = 4.003, 3.741, 7.862). The area under the ROC curve on prognosis of sST2 (AUC = 0.820) was slightly higher than NT-proBNP (AUC = 0.769), but the difference was not statistically significant (P > 0.05). The prognosis value combined sST2 with NT-proBNP was significantly increased (AUC = 0.938). Conclusion The level of peripheral blood sST2 may be used toevaluaterisk stratification and prognosis in patients with AHF. It will be better to evaluatethe prognosis combining sST2 with other biomarkers such as NT-proBNP.

Key words： sST2 Acute heart failure Clinical heart function grade Prognosis

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	ZONG Bin

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ZONG Bin. Clinical value analysis of peripheral blood sST2 on risk stratification and prognosis in patients with AHF[J]. 中国医药导报, 2017, 14(26): 60-63.

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http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2017/V14/I26/60

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