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| Clinical study of puerarin combined with α-lipoic acid in the treatment of diabetes mellitus with carotid atherosclerosis |
| HE Guixiang1 MA Yunhui2 LIU Haiyan1 ZHONG Yi3 |
1.Department of Endocrinology, Ansteel Group Hospital, Liaoning Province, Anshan 114002, China;
2.Department of Geriatrics, Ansteel Group Hospital, Liaoning Province, Anshan 114002, China;
3.Dynamic Electrocardiogram, Ansteel Group Hospital, Liaoning Province, Anshan 114002, China |
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Abstract Objective To investigate the clinical effect of puerarin combined with α-lipoic acid in the treatment of diabetes mellitus with carotid atherosclerosis. Methods A total of 122 patients with diabetes mellitus complicated with carotid atherosclerosis admitted to Ansteel Group Hospital from January 2015 to January 2019 were selected and they were divided into the control group and the study group according to the random number table method, with 61 cases in each group. The control group was treated with α-lipoic acid on the basis of routine treatment, and the study group was treated with α-lipoic acid on the basis of the control group. The clinical efficacy, glucose and lipid metabolism indexes and oxidative stress indexes of the two groups were compared, and the occurrence of adverse reactions of the two groups during treatment was recorded. Results After one month of treatment, the total clinical effective rate of the study group was higher than that of the control group, and the difference was statistically significant (P ＜ 0.05). Before treatment, there was no statistically significant difference between the two groups in glycosylated hemoglobin (HbA1c), total cholesterol (TC), triglyceride (TG), low-density lipoprotein (LDL) and high-density lipoprotein (HDL) (P ＞ 0.05). After one month of treatment, there was no significant difference in HbA1c between the two groups (P ＞ 0.05). In both groups, TC, TG and LDL decreased and HDL increased compared with that before treatment, and TC, TG and LDL in the study group were lower than those in the control group and HDL was higher than those in the control group, with statistically significant differences (all P ＜ 0.05). There was no statistically significant difference in serum superoxide dismutases (SOD) and malondialdehyde (MDA) levels between the two groups before treatment (P ＞ 0.05). After one month of treatment, SOD increased and MDA decreased in the two groups, and SOD in the study group was higher than that in the control group, while MDA was lower than that in the control group, with statistically significant differences (all P ＜ 0.05). There was no statistically significant difference in the incidence of adverse reactions between the two groups (P ＞ 0.05). Conclusion Puerarin combined with α-lipoic acid in the treatment of diabetes mellitus with carotid atherosclerosis has a significant effect, and can effectively improve the level of blood lipid and oxidative stress index in patients, with a good safety and high clinical application value.
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[1] 刘玉静，纪品川，刘亚茹.针刺联合二甲双胍用于糖尿病前期的治疗[J].国际中医中药杂志，2019，41（5）：454-457.
[2] Wang C，Zhang W，Wang Y，et al. Novel associations between sex hormones and diabetic vascular complications in men and postmenopausal women：a cross-sectional study [J]. Cardiovasc Diabetol，2019，18（1）：97.
[3] 李改仙，张虹，刘萍，等.牛痘疫苗接种家兔炎症皮肤提取物联合α-硫辛酸治疗老年痛性糖尿病性神经病变的效果及机制[J].中国老年学杂志，2018，38（5）：1065-1067.
[4] 孙玉娇，陈璇.糖尿病中医辨证施护的研究现状及展望[J].护士进修杂志，2017，32（3）：225-229.
[5] 罗春，步世忠，王福艳，等.葛根素治疗2型糖尿病的药理机制和临床进展[J].基础医学与临床，2016，36（11）：1582-1585.
[6] 中华医学会糖尿病学分会.中国2型糖尿病防治指南（2010年版）[J].中国糖尿病杂志，2012，20（1）：54-109.
[7] 吕仁和.消渴病（糖尿病）中医分期辨证疗效评定标准[C].中华中医药学会糖尿病分会.糖尿病（消渴病）中医诊治荟萃--全国第五次中医糖尿病学术大会论文集.中华中医药学会糖尿病分会：中华中医药学会糖尿病分会，1999：374-376.
[8] 郑筱萸.中药新药临床研究指导原则（试行）[M].北京：中国医药科技出版社，2002.
[9] 郑洲.代谢手术改善肥胖合并2型糖尿病患者血管舒张功能及相关机制[D].重庆：第三军医大学，2013.
[10] Joy SS，George TP，Siddiqui K. Low magnesium level as an indicator of poor glycemic control in type 2 diabetic patients withcomplications [J]. Diabetes Metab Syndr，2019，13（2）：1303-1307.
[11] 靳瑾，李英，薛以贵，等.舒洛地特对糖尿病大血管病变大鼠血管内皮生长因子的干预作用[J].中国现代医学杂志，2015，25（17）：12-15.
[12] 陈明云，李连喜.糖尿病大血管病变的表观遗传学标志物[J].国际内分泌代谢杂志，2016，36（2）：139-142.
[13] 王小康，许耿瑞，吴铁松，等.葛根素抑制软脂酸诱导的小鼠3T3-L1细胞炎性因子的表达及其机制[J].中国临床药理学杂志，2018，34（9）：1077-1080.
[14] Ismawati，Mukhyarjon，Asni E，et al. The effect of alpha-lipoic acid on expression of VCAM-1 in type 2 diabetic rat [J]. Anat Cell Biol，2019，52（2）：176-182.
[15] 李国峰，秦玉花，杜鹏强，等.葛根素对缺氧复氧心脏微血管内皮细胞的保护作用[J].中国医院药学杂志，2016， 36（1）：37-40.
[16] 黄华，丁菁，粟凤，等.葛根素预处理上调内皮型一氧化氮合酶的表达减轻人脐静脉内皮细胞缺氧/复氧损伤[J].中国病理生理杂志，2016，32（5）：857-862.
[17] 程文静，张晓雪，张磊，等.葛根素联合依达拉奉对急性脑梗死患者炎症因子的影响[J].中国中医急症，2016， 25（2）：245-247.
[18] 王泽，张永涛，李珊，等.葛根素在脑缺血再灌注损伤时对局部肾素-血管紧张素系统的影响[J].中国医药导报，2018，15（2）：9-12，35.
[19] 张剑，韩方菊.葛根素对糖尿病性白内障大鼠模型病情进展的影响[J].中国老年学杂志，2018，38（9）：2195-2196.
[20] 都君君，刘洪伟.葛根素对妊娠期糖尿病模型大鼠脑组织氧化应激和细胞凋亡的影响[J].中医学报，2018，33（8）：1407-1410. |
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