心房颤动患者血清25羟基维生素D、IL-10及左心房直径变化及意义

Abstract
Figure/Table
References (20)
Related Citation (15)

Download: PDF (661 KB) HTML (1 KB)
Export: BibTeX | EndNote (RIS)

Abstract Objective To observe the changes of serum 25-hydroxivitamin D [25(OH)D], interleukin-10 (IL-10) and left atrial diameter (LAD) in patients with atrial fibrillation, and to explore their relationship with atrial fibrillation. Methods A total of 111 patients with atrial fibrillation admitted to the Department of Cardiovascular Medicine, Zigong First People′s Hospital (hereinafter referred to as “our hospital”) from December 2011 to December 2012 were selected as the research group, including 20 patients with paroxysmal atrial fibrillation, 40 patients with persistent atrial fibrillation and 51 patients with permanent atrial fibrillation. Another 109 cases of non-atrial fibrillation patients hospitalized in the Department of Cardiovascular Medicine of our hospital at the same time were selected as the control group. Serum 25(OH)D and IL-10 were detected by ELISA, LAD was measured by echocardiography and they were compared. Results The levels of 25(OH)D and IL-10 in the study group were significantly lower than those in the control group, and the LAD was higher than that in the control group, with statistically significant differences (all P ＜ 0.05). Serum 25(OH)D and IL-10 levels and LAD of patients with different atrial fibrillation types in the study group showed statistically significant differences (all P ＜ 0.05). Compared with the persistent atrial fibrillation group, 25(OH)D and IL-10 levels decreased and LAD increased in the permanent atrial fibrillation group, with statistically significant differences (all P ＜ 0.05). Compared with the paroxysms atrial fibrillation group, 25(OH)D and IL-10 levels decreased and LAD increased in the persistent atrial fibrillation group and permanent atrial fibrillation group, with statistically significant differences (all P ＜ 0.05). Conclusion In patients with atrial fibrillation, 25(OH)D, IL-10, and LAD are closely related to the occurrence and development of atrial fibrillation.

Key words： Atrial fibrillation 25-hydroxivitamin D Interleukin-10 Left atrial diameter

	Service

	E-mail this article
	Add to my bookshelf
	Add to citation manager
	E-mail Alert
	RSS
	Articles by authors
	CAO Wenzhai1 ZHANG Ting2 ZENG Rui3

Cite this article:

CAO Wenzhai1 ZHANG Ting2 ZENG Rui3. Changes and significance of serum 25-hydroxivitamin D, IL-10 and left atrial diameter in patients with atrial fibrillation[J]. 中国医药导报, 2020, 17(10): 78-81.

URL:

http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2020/V17/I10/78

[1] 黄从新.中国房颤导管消融现状[J].医学与哲学（B），2016， 37（11）：10-13.
[2] Zhou Z，Hu D. An epidemiological study on the prevalence of atrial fibrillation in the Chinese population of mainland China [J]. J Epidemiol，2008，18（5）：209-216.
[3] 陈发秀，宁芳，彭乐，等.维生素D与心房颤动的研究进展[J].中国骨质疏松杂志，2016，22（8）：1073-1076.
[4] Bikle DD. Extraskeletal actions of vitamin D [J]. Ann N Y Acad Sci，2016，1376（1）：29-52.
[5] 杨静，丁雪峰，何浩，等.IL-17、IL-6和IL-10因子在急性冠状动脉综合征的作用机制[J].基因组学与应用生物学，2019，38（9）：4329-4334.
[6] Ribeiro IS，Pereira IS，Santos DP，et al. Association between body composition and inflammation： A central role of IL-17 and IL-10 in diabetic and hypertensive elderly women [J]. Exp Gerontol，2019，127：110734.
[7] 陈志坚，易桂文.2016年ESC心房颤动管理指南更新解读[J].临床心血管病杂志，2016，32（11）：1076-1078.
[8] 赵亚楠，王贺，邱承杰，等.心房重构、氧化应激在心房颤动发病中作用机制的研究进展[J].山东医药，2018，58（43）：96-99.
[9] 刘铁成.急性心房扩张对心房电重构、ANP及NO合成与分泌的影响[D].天津：天津医科大学，2016.
[10] 王运，刘铁成，刘恩照，等.急性心房扩张对心房电重构及相关因子的影响[J].中华老年心脑血管病杂志，2019， 21（6）：637-640.
[11] 郝韦韦，张苏丽，孙艳，等.血管紧张素Ⅱ-1型受体自身抗体通过激活心肌成纤维细胞参与心肌纤维化[J].生理学报，2018，70（4）：343-353.
[12] Chen D，Li Z，Bao P，et al. Nrf2 deficiency aggravates Angiotensin II-induced cardiac injury by increasing hypertrophy and enhancing IL-6/STAT3-dependent inflammation [J]. Biochim Biophys Acta Mol Basis Dis，2019，1865（6）：1253-1264.
[13] Ragab D，Soliman D，Samaha D，et al. Vitamin D status and its modulatory effect on interferon gamma and interleukin-10 production by peripheral blood mononuclear cells in culture [J]. Cytokine，2016，85：5-10.
[14] Mirhosseini NZ，Knaus SJ，Bohaychuk K，et al. Both high and low plasma levels of 25-hydroxy vitamin D increase blood pressure in a normal rat model [J]. Br J Nutr，2016，116（11）：1889-1900.
[15] Chen WR，Liu ZY，Shi Y，et al. Relation of low vitamin D to nonvalvular persistent atrial fibrillation in Chinese patients [J]. Ann Noninvasive Electrocardiol，2014，19（2）：166-173.
[16] Belen E，Aykan AC，Kalaycioglu E，et al. Low-Level Vitamin D Is Associated with Atrial Fibrillation in Patients with Chronic Heart Failure [J]. Adv Clin Exp Med，2016， 25（1）：51-57.
[17] Ozcan OU，Gurlek A，Gursoy E，et al. Relation of vitamin D deficiency and new-onset atrial fibrillation among hypertensive patients [J]. J Am Soc Hypertens，2015，9（4）：307-312.
[18] 周亮，李小燕，黄月华.白细胞介素10对慢性乙型肝炎患者自然杀伤细胞的调控作用[J].临床肝胆病杂志，2016，32（8）：1600-1603.
[19] Nitahara-Kasahara Y，Hayashita-Kinoh H，Chiyo T，et al. Dystrophic mdx mice develop severe cardiac and respiratory dysfunction following genetic ablation of the anti-inflammatory cytokine IL-10 [J]. Hum Mol Genet，2014，23（15）：3990-4000.
[20] 吉顺年，王永年，邓新桃，等.白细胞介素10水平与心房颤动相关性的研究[J].中西医结合心血管病电子杂志，2015，3（8）：9-10，12.