抑郁症患者胶质细胞源性神经营养因子、Nod样受体蛋白3炎症小体表达水平及其诊断价值

Abstract
Figure/Table
References (24)
Related Citation (15)

Download: PDF (769 KB) HTML (1 KB)
Export: BibTeX | EndNote (RIS)

Abstract Objective To investigate the changes of glial cell-derived neurotrophic factor (GDNF) and nod-like receptor protein 3 (NLRP3) inflammasome in major depressive disorder patients and analyze the diagnostic value. Methods A total of 100 patients with major depressive disorder admitted to the Department of Affective Disorder, Ningbo Kangning Hospital (“our hospital” for short) from January 2018 to June 2019 were selected as the depression group. A total of 60 healthy people underwent routine physical examination in our hospital during the same period were selected as the control group. The expression of serum GDNF and NLRP3 inflammasome were compared between the two groups of patients and patients with depression of different severity. The correlation between the severity of depression and the diagnostic efficacy of GDNF and NLRP3 inflammasome single test and combined test in diagnosing depression were calculated. Results The level of GDNF in the depression group was significantly lower than that of the control group, and the serum NLRP3 level of the inflamatome was significantly higher than that of the control group, with statistically significant differences (all P ＜ 0.05). The levels of GDNF and NLRP3 in patients with depression of different severity were statistically significant differences (P ＜ 0.05). Compared with the mild depression group, the GDNF level in the moderate depression group and the severe depression group were decreased and the NLRP3 inflammasome was increased, the differences were statistically significant (all P ＜ 0.05). Compared with the moderate depression group, the GDNF level in the severe depression group were decreased and the NLRP3 inflammasome was increased, the differences were statistically significant (all P ＜ 0.05). The expression level of GDNF was negatively correlated with the severity of depression (r = -0.603, P ＜ 0.05), while the expression level of serum NLRP3 inflamosome was positively correlated with the severity of depression (r = 0.762, P ＜ 0.05). The sensitivity and specificity of combined detection of GDNF and NLRP3 inflammasome in diagnosing depression were significantly higher than that of single detection of GDNF and NLRP3 inflammasome and the combined detection has good specificity. Conclusion The abnormal expression of GDNF and serum NLRP3 inflammarosome is closely related to the occurrence and development of depression, and the combined detection of GDNF and NLRP3 inflammarosome is helpful for the diagnosis and condition evaluation of depression.

Key words： Depression Glial cell-derived neurotrophic factor Nod-like receptor protein 3 inflammasome Diagnostic value

	Service

	E-mail this article
	Add to my bookshelf
	Add to citation manager
	E-mail Alert
	RSS
	Articles by authors
	TIAN Haihua1 LIU Jimeng2 XU Guoan2 LI Guangxue2 WAN Xiaohan2
	3 ZHANG Jiao2
	3 GAO Shugui2

Cite this article:

TIAN Haihua1 LIU Jimeng2 XU Guoan2 LI Guangxue2 WAN Xiaohan2,3 ZHANG Jiao2,3 GAO Shugui2. Expression level and the diagnostic value of glial cell line-derived neurotrophic factor and Nod-like receptor protein 3 inflammatory in patients with depression[J]. 中国医药导报, 2020, 17(8): 148-151.

URL:

http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2020/V17/I8/148

[1] 崔旅纯，吴志国，方贻儒．抑郁症症状维度与诊治效应研究进展[J].中华精神科杂志，2018，51（4）：269-272．
[2] Smith K. Mental health：a world of depression [J]. Nature，2014，515（7526）：181.
[3] 苑杰，严辞，刘昊，等.抑郁症生物标志物研究进展[J].国际精神病学杂志，2015，21（2）：103-107.
[4] 陈思路，季卫东，易正辉.德尔菲法确定首次抑郁发作核心症状的诊断指标[J].青岛大学学报：医学版，2018，54（4）：10-14.
[5] 周俊杰，周大金.脑源性神经营养因子与抑郁症的相关性分析[J].现代实用医学，2019，31（4）：85-86.
[6] 汪崇泽，盛国红.免疫炎症途径与抑郁症的研究进展[J].精神医学杂志，2015，28（5）：397-400.
[7] 王贵锋，庞妩燕，王丽，等.帕罗西汀联合二甲双胍对糖尿病合并抑郁症患者AQP4、S100B、GDNF及BDNF的影响[J].国际精神病学杂志，2018，45（6）：73-75.
[8] Zhu X，Gao R，Liu Z，et al. Ginsenoside Rg1 reverses stress-induced depression-like behaviors and BDNF expression within the prefrontal cortex [J]. Eur J Neurosci，2016，44（2）：1878-1885.
[9] Daniels MJD，Rivers-Auty J，Schilling T，et al. Fenamate NSAIDs inhibit the NLRP3 inflammasome and protect against Alzheimer′s disease in rodent models [J]. Nat Commun，2016，7：12504.
[10] Kaufmann FN，Costa AP，Ghisleni G，et al. NLRP3 inflammasome-driven pathways in depression：Clinical and preclinical findings [J]. Brain Behav Immun，2017，64：367-383.
[11] Hoseini Z，Sepahvand F，Rashidi B，et al. NLRP3 Inflammasome： Its Regulation and Involvement in Atherosclerosis [J]. J Cell Physiol，2018，233：2116-2132.
[12] Gaidt MM，Hornung V. The NLRP3 Inflammasome Renders Cell Death Pro-inflammatory [J]. J Mol Bio，2017， 430（2）：133-141.
[13] Al-Hakeim HK，Al-Rammahi DA，Al-Dujaili AH. IL-6，IL-18，sIL-2R，and TNFα proinflammatory markers in depression and schizophrenia patients who are free of overt inflammation [J]. J Affect Disord，2015，182：106-114.
[14] Bahrini L，Ouanes S，Ghachem R. Inflammatory profile in depression and associated clinical and sociodemographic features in a Middle-Eastern North-African population [J]. J Affect Disord，2016，198：122-126.
[15] Stahl SM. The last Diagnostic and Statistical Manual（DSM）：replacing our symptom-based diagnoses with a brain circuit-based classification of mental illnesses [J]. CNS Spectr，2013，18（2）：65-68.
[16] Lin CH，Park C，Mcintyre RS. Early improvement in HAMD-17 and HAMD-7 scores predict response and remission in depressed patients treated with fluoxetine or electroconvulsive therapy [J]. J Affect Disord，2019，253：154-161.
[17] Park YM，Lee BH. Alterations in Serum BDNF and GDNF Levels after 12 Weeks of Antidepressant Treatment in Female Outpatients with Major Depressive Disorder [J]. Psychiatry Investig，2018，15（8）：818-823.
[18] Yang Y，Xie B，Ju C，et al. The Association of Decreased Serum Gdnf Level with Hyperglycemia and Depression in Type 2 Diabetes Mellitus [J]. Endocr Pract，2019，25（9）：951-965.
[19] 王梅，程韬，杨开仁，等.抑郁症患者血清脑源性神经生长因子、P物质、白细胞介素-6水平变化及临床意义[J]. 中国医药导报，2019，16（13）：95-98．
[20] 石珊珊，于春月，王琪，等.抑郁症患者血清补体通路差异蛋白的研究[J].医学综述，2018，24（18）：3719-3723.
[21] 马希权，熊伍军，刘璐，等.上海地区乙型肝炎患者焦虑和抑郁状况及相关因素调查[J].临床肝胆病杂志，2018，34（8）：1664-1668.
[22] 张熠，童卫杭，胡霜霜，等.健脾益气方联合氟哌噻吨美利曲辛片治疗卒中后抑郁症的效果观察[J].中国医药，2019，14（6）：879-883
[23] Wong ML，Inserra A，Lewis MD，et al. Inflammasome signaling affects anxiety- and depressive-like behavior and gut microbiome composition [J]. Mol Psychiatry，2016， 21（6）：797-805.
[24] Zhang Y，Liu L，Peng YL，et al. Involvement of Inflammasome Activation in Lipopolysaccharide-induced Mice Depressive-like Behaviors [J]. CNS Neurosci Ther，2014， 20（2）：119-124.