基于评估的优化治疗模式对精神分裂症患者代谢综合征的影响

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Abstract Objective To explore the effect of evaluation-based optimal treatment on metabolic syndrome (MS) in schizophrenia. Methods From March 2017 to March 2018, 120 cases with schizophrenia who diagnosed and treated in Hengshui Mental Hospital were selected. According to the random number table method, they were divided into study group and control group, with 60 cases in each group. Study group was taking Risperidone Tablets, and those with poor curative effects switched to Olanzapine. Control group was given Risperidone Tablets. Psychopathological symptoms were assessed using the negative and positive symptom scale (PANSS), and adverse drug reactions were assessed using the treatment emergent symptom scale (TESS). Fasting blood glucose (FBG), triglyceride (TG) and high density lipoprotein cholesterol (HDL-C) levels were recorded and compared between two groups. Results There was no significant difference in scores of positive symptoms, negative symptoms, general psychopathology and PANSS between two groups before treatment (P > 0.05). The scores of positive symptoms, negative symptoms, general psychopathology and PANSS at the end of the 4th week of treatment in two groups were lower than those before treatment, and the scores of positive symptoms and PANSS in study group were lower than those in control group, with statistically significant differences (all P < 0.05). The scores of positive symptoms, negative symptoms, general psychopathology and PANSS at the end of the 8th week of treatment in two groups were lower than those before treatment and the end of the 4th week of treatment, and the scores of general psychopathology and PANSS in study group were significantly lower than those in control group, with statistically significant differences (all P < 0.05). There was no significant difference in MS detection rate between two groups at different times (P > 0.05). There was no significant difference in body mass index (BMI), FBG, systolic blood pressure (SBP), diastolic pressure (DBP) and HDL-C between two groups before treatment (P > 0.05). TG level in study group was higher than that in control group, and the difference was statistically significant (P < 0.05). FBG and SBP levels at the end of the 4th week of treatment in study group were higher than before treatment, while BMI and HDL-C levels in control group were higher than before treatment, the levels of FBG and DBP in study group were higher than those in control group, with statistically significant differences (all P < 0.05). SBP level at the end of the 8th week of treatment in study group was lower than that at the end of the 4th week of treatment, TG level was higher than that at the 4th week of treatment, and FBG level was higher than that before treatment, BMI and DBP levels in control group were higher than those before treatment, TG and HDL-C levels in study group were higher than those in control group, with statistically significant differences (all P < 0.05). Compared with the 2th weekend of treatment, TESS scores in both groups were decreased at the 4th and 8th weeks of treatment; compared with the treatment group at the end of the 4th week, both groups had lower TESS scores at the end of the 8th week, and study group was lower than control group, with statistically significant differences (all P < 0.05). Conclusion The optimal treatment model based on evaluation is used to treat schizophrenia, which has better efficacy than traditional treatment model and has similar effects on metabolic syndrome.

Key words： Schizophrenia Evaluation Optimal treatment Metabolic syndrome

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	XI Lingyan1 JIN Guixing2▲ QIAO Jingshuang1 HUANG Xiuqin1 ZHANG Suyun1 ZHANG Qian1

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XI Lingyan1 JIN Guixing2▲ QIAO Jingshuang1 HUANG Xiuqin1 ZHANG Suyun1 ZHANG Qian1. Effect of evaluation-based optimal treatment on metabolic syndrome in schizophrenia[J]. 中国医药导报, 2020, 17(8): 92-96.

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http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2020/V17/I8/92

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