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| Effect of Yangxin Granules combined with Western medicine in the treatment of unstable angina pectoris and its influence on vascular endothelial function and inflammatory factors |
| WANG Haitao YANG Bo YANG Jingna PEI Lili |
| Department of Cardioloy, Qinhuangdao Muncipality Traditional Chinese Medicine Hospital, Hebei Province, Qinhuangdao 066000, China |
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Abstract Objective To explore the effect of Yangxin Granules combined with Western medicine in the treatment of unstable angina pectoris (UAP) and its influence on vascular endothelial function and inflammatory factors. Methods One hundred and fifty-eight patients with UAP admitted to Qinhuangdao Muncipality Traditional Chinese Medicine Hospital from January 2017 to January 2019 were selected and divided into single group and treatment group according to the random number table method. 79 patients in single group were treated with Western medicine, and 79 patients in treatment group were treated with Yangxin Granules + Western medicine, and they were treated for 2 weeks. Therapeutic efficacy, traditional Chinese medicine symptoms scores, vascular endothelial damage function and serum cytokines levels were observed in two groups. Results After treatment, the effect in treatment group was significantly better than single group (P < 0.05). After treatment, the scores of chest distress, chest pain, palpitation, fatigue, self perspiration, dizziness, pallor and mental fatigue in two groups were significantly lower than those before treatment (P < 0.05), and the scores in treatment group were lower than those in single group (P < 0.05). After treatment, the levels of nitric oxide and prostacyclin in two groups were significantly higher than those before treatment (P < 0.05), the levels of plasma endothelin and thromboxane A2 were significantly lower than those before treatment (P < 0.05), and the change range in treatment group was larger than that in single group (P < 0.05). After treatment, the levels of IL-6, intercelluar adhesion molecule-1, homocysteine and matrix metalloproteinase-9 in two groups were significantly lower than those before treatment (P < 0.05), and those in treatment group were lower than those in single group (P < 0.05). Conclusion Yangxin Granules combined with Western medicine has exact efficacy in treating UAP. And it can significantly relieve symptoms of angina pectoris, improve ischemic performance of electrocardiogram, protect vascular endothelial function and inhibit expression of serum cytokines.
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